That was tough

[MIKEMAN1020]

Seriously, I can do this all day. Flame on.

[Hidden]

Allow me to do it for you. Finally, an answer to those incredibly healthy, disease free, medicine free, thin as a pole people who have nothing wrong with them but ALLERGIES and RLS. Allergies aren't one of the conditions that trigger or worsen RLS. Or are they??? They are!!!

link.springer.com/article/1...

Histamine inhibits the release of dopamine. That's bad, very bad.

So you would think ANTI-histamines would help, but they don't and are just as bad as that dopamine reducing histamine.

I wonder if large quantities of vitamin c would help allergies and ipso facto, RLS as well? And it would also, maybe, help us extract more iron from our food.

Maybe there really is no such thing as primary and secondary RLS. Primary RLSers are just those people who we haven't figured out what that other condition is that is triggering their RLS. Maybe all people with RLS all have genetically defective dopamine receptors and then an environmental trigger. Only those we label as "primary" we haven't figured out the environmental trigger. So remind me again what the difference is between the two.

[nightdancer in reply to Hidden]

We know that just from the fact that 99% of all RLSer's cannot take the antihistamine Diphenhydramine, the main ingredient in Benedryl, as well as other allergy meds, over the counter sleep meds, etc. We have to become label readers. Also, pseudoepinephrine is on the "no no" list.

[Hidden in reply to nightdancer]

Actually, I'm not talking anti-histamine but rather "histamine." The substance that is released when you have an allergy may actually inhibit the release of dopamine.

[nightdancer in reply to Hidden]

Primary RLS is genetic, the genes were discovered in 2004 and 2007 and named. The Genetics of RLS is a proven thing. will get you that info when I have time. But there is real Primary RLS and there is real secondary RLS. Environmental triggers are in there somewhere. Both my sisters have RLS, my nieces, my oldest niece's kids who are 11 and 8. My mother has "minor" RLS, but the gene came from her, for sure. There was a very large study done on a very large family and out of over 100 members, 76% of them had RLS. They were all in different parts of the world, ate different diets, etc. The only commonality was the genetics.

[nightdancer in reply to nightdancer]

The main gene is named BTBD9 and is EASY to google. 3.2 seconds

[Hidden in reply to nightdancer]

Yes, I understand what you are saying. Kind of. But autopsies of brains of by now hundreds of people who claim to have had RLS during their lives show that our dopamine receptors in the part of the brain called the substania nigra, and specifically the d2 receptors were pathetic. I'm going to assume that they accepted everyone's brain, whether they had primary or secondary. The brains of these people were also severely iron deficient. Science knows, not from these experiment, that our receptors need iron to be healthy. So they surmise that our pathetic d2 receptors are caused by low iron levels in the brain. I believe they found this in all of the brains of the deceased RLS patients but not in any of the control brains. The scientists were quick to point out that none of these brains were diseased. The brains cells looked healthy and normal. It's just that the receptors were small and few. Women can have small breasts but that doesn't make them diseased. Lastly, they found normal levels of dopamine in all the brains they analyzed and in some cases, the high end of normal. It was further hypothesized that these high levels of dopamine in our brains is part of a feedback loop whereby our bodies (especially our legs and arms) cry out to the brain for more dopamine and it produces more dopamine but once again it goes nowhere because our receptors are VW Bugs rather than Ford Explorers.

So like I said, I believe that everyone with RLS has these too little too few D2 receptors. And that there is no significant difference between people who have RLS with no obvious other condition (primary RLS) and those that have say rheumatoid arthritis and RLS (secondary RLS).

More importantly, I want to explain something to you about the potassium that I recommended. Potassium is a dopamine agonist in every sense of the word. Meaning that it too will down-regulate/desensitize your d2 receptors over time. I could easily have recommend quinine to you as well. Only I believe that quinine is the most powerful dopamine agonist on earth and that it will start to down regulate your receptors from the first time. Iron, as far as I can tell, is not a dopamine agonist, but is essential for almost all body functions. Actually so is potassium. So maybe potassium won't down regulate? Anyways, I threw potassium out there because I want to give you some relief during attacks while you try the intermittent fasting. Intermittent fasting is not a dopamine agonist, if anything it is a dopamine antagonist. You will be hungry and angry and in need of dopamine while fasting. Through fasting, according to the articles, your d2 receptors will become re-sensitized and you may actually sprout some new ones.

I did not recommend the Uridine Monophosphate to you because I want to try it myself first. If you can believe this, Uridine is supposed to not only cause a release of dopamine like the agonists and opiates but also build up the receptors. Sounds too good to be true. But then again, it's a staple component in mother's milk so you would think that mother nature, in her infinite wisdom, would not give babies something that would down regulate their developing receptors, or be bad for them in anyway.

[Whitebuffalo in reply to Hidden]

That link isn't opening for me??? Do you have bad allergies?

[Hidden]

An ingredient in breast milk for RLS?

ncbi.nlm.nih.gov/pubmed/160...

[nightdancer in reply to Hidden]

From what I understand, uridine, which is what is being discussed in link you provided GoFish, it is mainly being targeted for treatment of bipolar disorder. And, all I see is studies on gerbals, and SMALL ones at that. I did a bit of "googling".

[Hidden in reply to nightdancer]

Fabulous, you don't have to tell me. My order is in. $23 for two month supply.

[Hidden]

Do you have bipolar gofish, is that why you have ordered it. ?

[Hidden in reply to Hidden]

Why the hate? Life is sacred. You're going to wither away and die never to have known that sacredness. I ordered this substance, that is contained in Mother's milk, to learn yet another life lesson. Because I am confident in the potential and knowledge of the human race. I do not believe in coincidence, I believe that everything that happens has meaning and purpose. Booklover's discovery about Digoxin, Pippins change of anti-depressants, and Sara's withdrawal from prescription drugs to iron and levo have meaning and purpose not just for themselves but for all of us.

I have not recommended this supplement to Windwalker because I have to experiment on my own body first. I do not recommend it to anyone. I cannot recommend anything I have not tried. I put this information out there as a possibility, a hope and because I truly believe that I came across it for a reason. Maybe the only reason is to help someone on here who is bi-polar.

Namaste Elisse

The divine light in me salutes the divine light in you.

[Hidden]

No hate coming from me. I just asked a question... if it is for bipolar than why you had ordered it.

[Whitebuffalo]

Hey Mikeman what do you mean by "flame on." Were you attacked or something?