I went thru the list of anti-d's over the years. I had my share of tricyclics and SSRI's and SNRI's. Mirtazapine is the only one that did NOT BOTHER my RLS, and I am also free of the panic attacks that would not let me leave my house. So, who are YOU, tcho, to criticize the medication I have been taking for years and now I can live my life almost "normally" now? I will say that there was one study done only on Remeron/Mirtazapine done for 12 wks on less than about 70 people, if that many. 28% reported worsened RLS, so that means that 72% did NOT report any worsened RLS. That is the only study that has been done to date. It is in a class of it's own. SOME very few people can take SSRI's, very few, without worsening symptoms. But, my own personal medications works for ME, because it does, and I always stipulate the usual disclaimer-"what works for one, does not necessarily work for the next person" and so on. You have a good night, hope all of us do.