A potential biomarker for fatigue

We sought to determine whether oxidative stress and anti-oxidative activity could act as biomarkers that discriminate patients with chronic fatigue syndrome (CFS) from healthy volunteers at acute and sub-acute fatigue and resting conditions.

We calculated the oxidative stress index (OSI) from reactive oxygen metabolites-derived compounds (d-ROMs) and the biological antioxidant potential (BAP). We determined changes in d-ROMs, BAP, and OSI in acute and sub-acute fatigue in two healthy groups, and compared their values at rest between patients with CFS (diagnosed by Fukuda 1994 criteria) and another group of healthy controls.

Following acute fatigue in healthy controls, d-ROMs and OSI increased, and BAP decreased. Although d-ROMs and OSI were significantly higher after sub-acute fatigue, BAP did not decrease.

Resting condition yielded higher d-ROMs, higher OSI, and lower BAP in patients with CFS than in healthy volunteers, but lower d-ROMs and OSI when compared with sub-acute controls.

BAP values did not significantly differ between patients with CFS and controls in the sub-acute condition. However, values were significantly higher than in the resting condition for controls.

Thus, measured of oxidative stress (d-ROMS) and anti-oxidative activity (BAP) might be useful for discriminating acute, sub-acute, and resting fatigue in healthy people from patients with CFS, or for evaluating fatigue levels in healthy people

sciencedirect.com/science/a...

3 Replies

oldestnewest
  • Fatigue is only one symptom testing how tired maybe tells a doctor something new but adds nothing new I did not already tell them if they listened.

    PEM is more than tired it is the worsening of all symptoms a marker for that is worth more than a tired test using over 20 year old criteria.

  • CPET (cardio pulmonary exercise testing) already exists as a biomarker of fatigue in me/cfs ncbi.nlm.nih.gov/pubmed/247...

  • Tells them apart from healthy controls what about other diseases that have symptoms that look like CFS but aren't the same at all.