Re: Stem Cell caution

[enjoysalud]

enewspaper.latimes.com/infi...

Hope is good, but hope can also lead us astray.

[Kevin_1]

Thank you Enjoysalud,

This link won't work in Europe. (Unless using aa VPN)

I have pasted the article below.

I am surprised that it is legal to use unlicensed treatments in Portugal...

From the LA Times

Tragic results of stem cell ‘cures’

MICHAEL HILTZIK

Medical regulators have been warning that the downside of unproven stem cell treatments isn’t merely that they won’t work, but that they can be life-threatening.

A team of Canadian physicians has just reported an especially gruesome example of what can go wrong when desperate patients chase after last-ditch cures in what’s known as stem cell tourism. Their subject is a 38-year-old Newfoundland man who became a paraplegic after a trampoline accident at the age of 20 injured his spinal column.

Six years later, he traveled to Portugal for a stem cell treatment. Doctors there transplanted olfactory mucosal cells drawn from his upper nasal passages into the site of his spinal injury. He never got better, but years later started getting worse.

Doctors at Memorial University of Newfoundland discovered that the olfactory cells had never differentiated into neuronal cells, as the Portuguese clinic apparently expected, but kept growing on their own, producing a tumor of nasal cells that’s now too large to be surgically removed.

“This was a young man with a life-altering injury and would have tried anything for a chance to walk again,” Nanette Hache, one of the physicians, told me. The Portuguese operation cost $50,000, plus possibly that much more for travel, accommodations and postoperative support. The doctors published (with the patient’s consent) “because we want to make sure the same thing doesn’t happen to anyone else.”

As many as three other similar cases have been identified in scientific journal reports, according to Leigh Turner, a bioethicist at the University of Minnesota who has been tracking the proliferation of unproven stem cell treatments for several years. All went to the same clinic in Portugal, which has claimed to have treated more than 120 patients.

Medical experts have started warning in earnest of the hazards of stem cell tourism. As regulators in the U.S., Canada and parts of Europe have cracked down on promoters of stem cell treatments that have no scientific validity, clinics in less-regulated locales have stepped into the void. These promoters are not only relatively unaccountable to government oversight, they often can avoid reporting negative outcomes of their handiwork that might warn off potential victims.

Last year, Berlin-based researchers compiled a list of 35 adverse incidents resulting from unproven stem cell treatments performed mostly in China, Thailand, Argentina, Mexico, Costa Rica, Egypt, Dominican Republic and Russia. Some were done in Germany, Australia and the U.S. as well. The negative outcomes included tumors, blindness, brain hemorrhages, strokes, pneumonia and death.

The researchers observed, however, that their list was almost certainly incomplete, in part because the true number of treatments is unknown. The evidence at hand, however, indicated “substantial patient exploitation using the ‘power of hope.’ ”

Credulous media reports add to the dangers. Consider the recently reported experience of Caroline Wyatt, a prominent BBC journalist who at the age of 49 underwent a stem cell treatment for multiple sclerosis in Mexico in 2017, lured there by reports (on the BBC) of “near miraculous results.” She raised $84,000 from friends and family, because Britain’s health system wouldn’t cover the procedure. A month after her treatment, she told a BBC news program that she was “feeling better than I have done in a long time.”

The improvement didn’t last. In a follow-up report in February, she acknowledged that “today, I often feel worse than I did before.” Of the patients she has kept in contact with, some reported improvements, but others little change. “A few have said that they now feel worse than they ever did before ... and wish they had never had the treatment.” As she acknowledges, the causes of MS — and therefore the proper treatments — are unknown.

Clinics offering stem cell-based nostrums in the U.S. typically use cells derived from fat, removed from patients by liposuction, purportedly treated to concentrate the stem cells, which are then injected into a customer’s body.

The use of olfactory cells appears to be a relatively novel application for spinal cord injuries. The process isn’t utterly devoid of scientific logic. Olfactory mucosal cells have neuronal features and are known to regenerate themselves, which suggests they could fulfill the function of spinal cells, which don’t regenerate, at least in theory.

“It’s not entirely ‘out there,’ ” Hache says. “Legitimate research is being done, but as for the next leg, transplanting them in patients — we’re not there yet.”

One problem made evident from the Newfoundland case and others is that the tumors caused by the transplants may not develop for years. The Portuguese clinic, which reported on the experiences of 20 patients in 2010, followed up on the patients only for an average of about two years and none for more than four.

The Newfoundland patient’s tumor, however, didn’t make its presence known for more than seven years after his transplant, and then only because his condition was worsening as the tumor grew.

The lesson, Turner says, is that “if you put the wrong kind of cells in the wrong place bad things can happen, even if symptoms don’t manifest right away.”

[enjoysalud in reply to Kevin_1]

Wow, Kevin_1, thank you for doing the conversion on this article. That was kind of you. I have heard from others in the UK that they cannot open websites that I have posted, but I go ahead. I figure those in the USA will benefit and maybe "this time" it can be opened.

I often read about the danger of stem cell experimentation , but never with the suffering it can ACTUALLY create. I just have thought that stem cell failure leaves you where you are (the optimist in me). Interesting that failures have occurred in Germany, the USA, etc.

Thanks again, Margarita

[Kevin_1 in reply to enjoysalud]

You're most welcome Margarita,

The reason why those in Europe can't open some American websites is that Europe brought in quite strict regulations regarding online privacy and websites are required to warn people if they are using cookies.

A 'Virtual Private Network' allows the user to move their web access point (the country their computer appears to be located) to any country they choose as well as hiding their identity. It's a web security and privacy tool. So I 'virtually' located myself in the US to read the article.

Yes, I didn't realise just how dangerous Stem Cell treatments could be. What shocks me the most is that these treatments are being offered in Germany and Japan. Two very highly regulated countries.

Again thank you for posting that article.

Kevin

[enjoysalud in reply to Kevin_1]

I am not sophisticated on computer/internet. That is good that you are. In the past, when others outside of the USA have let me know they couldn't open the website that I have posted, I asked them to GOOGLE the site. Some wrote back and said "THANKS".

In the future, I think to not complicate my life more, I will post a comment that those outside of the USA may not able to open the website address.

Time for breakfast and then church.

Los Angeles, CA, USA

[Kevin_1 in reply to enjoysalud]

No problem

But you do find valuable information. I am happy to cut and paste articles if you post a link which won't work here.

Be well

[enjoysalud in reply to Kevin_1]

Thank you!

[LuisRodicioRodicio in reply to Kevin_1]

Thanks Kevin.

Hug.