Ultrasound treatment of neurological diseases — current and emerging applications

I am extremely interested in this approach to treat neurological diseases. May be thisis the only way to "reverse" the damages. I wonder if anyone has heard of any similar work in other countriesor research centers.

Ultrasound treatment of neurological diseases — current and emerging applications

    Gerhard Leinenga,   

    Christian Langton,   

    Rebecca Nisbet   

    & Jürgen Götz   

    Nature Reviews Neurology

    19 February 2016


Like cardiovascular disease and cancer, neurological disorders present an increasing challenge for an ageing population. Whereas nonpharmacological procedures are routine for eliminating cancer tissue or opening a blocked artery, the focus in neurological disease remains on pharmacological interventions. Setbacks in clinical trials and the obstacle of access to the brain for drug delivery and surgery have highlighted the potential for therapeutic use of ultrasound in neurological diseases, and the technology has proved useful for inducing focused lesions, clearing protein aggregates, facilitating drug uptake, and modulating neuronal function. In this Review, we discuss milestones in the development of therapeutic ultrasound, from the first steps in the 1950s to recent improvements in technology. We provide an overview of the principles of diagnostic and therapeutic ultrasound, for surgery and transient opening of the blood–brain barrier, and its application in clinical trials of stroke, Parkinson disease and chronic pain. We discuss the promising outcomes of safety and feasibility studies in preclinical models, including rodents, pigs and macaques, and efficacy studies in models of Alzheimer disease. We also consider the challenges faced on the road to clinical translation.

1 Reply

  • Interesting.  I take it that have not yet started clinical trials on humans?

    Thank you for the write


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