Hi, just an update on my wife Sharyn who as PSP. When we saw the Neurologist last he and Sharyn and I didn't think the Carbadopa/Levadopa she was taking was working. She was on it, things didn't change, then off it, things didn't change. We thought there might be some VERY sight benefit that maybe we weren't seeing so she went back on it. That was a year ago. The neurologist said "Lets get off it and try Amantadine" we agreed. So we gradually reduced the amount of Carba/Leva to zero over a week. Surprise! Shock! Sharyn went totally bad. She went from being somewhat stable to hardly being able to stand and walk. I quickly emailed the neurologist asking what to do. He and we agreed to not try Amantadine and get back on Carba/Leva which we did, a small dose for starters. Well it made the best improvement you could imagine. So we are now very happy again. Just shows that this PSP is sometimes a trial-and-error type of deal. I understand that Carba/Leva sometimes only works for a period of time with PSP patients but a least it's working for us now. I abreviated to Carba/Leva after spelling it out the first time above.