Just returned this week from our neurologist at University of Florida Neurological Clinic. He said to ease down until totally off Sintement (Carbadopa/Levadopa). Why, because we have been on it, off it, on it, off, it, on it, and don't detect any change. He is suggesting we try Amantadine which is to help with rigidity and motion he says. I've read the side effects which as most drugs are scarry. Just looking for someone who tried it and has comments about it. That's the beauty of this group, we can open up honestly about anything related to PSP. Thanks in advance for your response.