billd9946 in reply to Tall_Allen

Thanks, Allen. One question- are you familiar with peripheral hormone blockade therapy? My medical oncologist has mentioned this as a replacement for full ADT, but only after 6 or more months of ADT, and after SR has been completed. My understanding is that peripheral hormone blockade therapy does not deplete testosterone, yet it prevents it from feeding the prostate cancer cells.

Tall_Allen in reply to billd9946

I think you're talking about bicalutamide. It's not as good, but if that's the most you can tolerate, it's better than nothing.

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JPnSD in reply to Tall_Allen

Thank you again for the support documents. I am facing SRT in 2 months after starting Firmagin this week. I was trying to lose weight (5'10" and 195) due to anticipated ADT weight gain...now 2nd thoughts given your bear comment. So much info...so many decisions

billd9946 in reply to spencoid2

Hi Spencoid2. I had the same issue then discovered through my radiation oncologist that Chesapeake Urology in Baltimore was sponsoring a trial. I contacted them myself, was accepted, and within a week had the scan, I also discovered during my research that UCLA Medical Center offers the scan, but there is an out of pocket cost associated. Other trials are going on at NIH and Memorial Sloan Kettering, but I could not get into either of these for one reason or another.

My PSA level is fairly low at .41 currently. I’ve read that at this low level, the PSMA scan will only detect cancer in approximately 30% of patients. The growth has to be a certain size in order to be detected. My medical oncologist and radiation oncologist have explained to me that even though the scan shows nothing, there could be microscopic cancer in the prostate bed, or maybe pelvic lymph nodes. It is also possible there is cancer elsewhere, but still undetectable. If it’s still contained in the pelvic area, radiation therapy could be curative. It’s a shot in the dark, but seems statistically worth it. If the scan had shown cancer had metastasized outside the pelvic region, salvage radiation would not be a viable option,

Hope this helps.

spencoid2 in reply to billd9946

Thanks for the info. I wrote to the coordinators of the UCLA study and it seems that i can get a scan in 2 to 3 weeks at a cost of under $3000. I will call my oncologist tomorrow and also on the results of the recent biopsy decide whether it will be useful to get the scan. I can get just a single scan and can fly there from the local airport with minimal effort. The location is 10 miles from the airport. Not much more effort than going to SF and UCLA answered on a Sunday within 8 hours of my inquiry.

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billd9946 in reply to JockoJake

Thank you... good to know! Best of luck to you, too!!

billd9946 in reply to JPnSD

Hello JP! I’m probably not the best person to ask, but I’ll tell you... my testosterone was depleted like immediately, so sex drive totally out the window. I began having hot flashes pretty much right away, and they were frequent. I purchased a hand sized fan that plugs into a USB port and kept it handy, and it really did help. The worst of it was that the shot made me so depressed. I battle anyway with depression, but this shot really exacerbated the issue. I only had 1 shot to prepare for the start of salvage radiation, but decided to hold off. Now 4 years later with a rising PSA, I’m looking at starting all over again. A single shot depleted me of all testosterone for 8 long months. I wish now that I had just done the salvage radiation, given how long my testosterone was gone. All this said, you might tolerate the shot way better than I did. Everyone is different and sometimes we just gotta do what we gotta do. Hang in there and I wish you the absolute best! Try exercising as much as you can. Testosterone depletion does affect your body composition, so exercise will help physically, as well as emotionally. Let me know if you have any other questions.