What is done in this case ? ADT not working

[Alfy47]

In may of 2011 the PSA and Biopsy showed that I had an agressive cancer with Gleason 8 so my prostate was extracted and after this I received radiotherapy. Since during the following 9 years my psa continued very low, I suspended checking it and last september I received the surprise that it had increased to 9 ng. The magnetic resonance and the PET confirmed that it has extended now to the lymph nodes near the prostate and the doctor prescribed me ADT , Zoladex and Xtandi for 9 months and checking it's effects today , after the first 3 months were completed I noticed that it is not working because the psa is now 16 ng, higher than 6 months before. Does this has happened and what options are there for a case like this? Thanks for any comment and opinion.

[Tall_Allen]

ADT (Zoladex) always "works" in that it prevents your testes from making testosterone. However, the cancer learns how to grow despite the lack of testosterone. The growth would be more rapid without ADT, so you have to keep taking it.

Your cancer has become resistant to Xtandi too. When that happens, adding docetaxel to Xtandi can keep it working:

prostatecancer.news/2022/10...

If the cancer is only in your pelvic lymph nodes, whole pelvic radiation may be able to destroy the cancer.

[Alfy47 in reply to Tall_Allen]

My thanks for your response!