Honokiol, a natural plant product, in... - Prostate Cancer N...

Prostate Cancer Network

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Honokiol, a natural plant product, inhibits the bone metastatic growth of human prostate cancer cells

Barbarino-BK profile image

Honokiol, a natural plant product, inhibits the bone metastatic growth of human prostate cancer cells

Results:

Honokiol induced apoptosis in all cell lines tested. In PCa cells honokiol induced apoptosis via the activation of caspases 3, 8, and 9 and the cleavage of poly-adenosine diphosphate ribose polymerase in a dose- and time-dependent manner. Honokiol was shown to inhibit the growth and depress serum PSA in mice harboring C4-2 xenografts in the skeleton and the combination with docetaxel showed additive effects that inhibited further growth without evidence of systemic toxicity. Immunohistochemical staining confirmed honokiol exhibited growth-inhibitory, apoptotic, and antiangiogenic effects on PCa xenografts.

Conclusions:

The combination of honokiol and low-dose docetaxel may be used to improve patient outcome in androgen-independent prostate cancer with bone metastasis.

pubmed.ncbi.nlm.nih.gov/173...

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Honokiol Inhibits Androgen Receptor Activity in Prostate Cancer Cells

"The present study demonstrates, for the first time, that HNK inhibits activity of AR in prostate cancer cells regardless of the p53 status."

ncbi.nlm.nih.gov/pmc/articl...

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10 Replies

There are lots of papers showing the benefits of honokiol in a number of cancers. The problem is bioavailability. Mitochondria targeted honokiol seems to overcome the problem, but outside of the lab, where would you get hold of it? Maybe NAL would know how to make it. A job fur him when he's tired of fishing....

SoFlaGtr954 profile image
SoFlaGtr954 in reply to TFBUNDY

EcoNugenics sells a product called HonoPure.

“HonoPure is 98% pure honokiol—an extensively researched, highly active extract purified from Magnolia officinalis bark. HonoPure provides a remarkable range of potent benefits including cognitive and neurological support, cellular regulation, relaxation and healthy mood, and more.*”

Lulu700 profile image
Lulu700 in reply to SoFlaGtr954

It’s the one! 👏👏

'Nalakrats' has posted on this topic - try searching for it .... he's on a sabbatical for now ......

Thanks!

My wife and I take one cap of HonoPure every night just before going to bed. It helps us both sleep through the night. Try it.

Lulu700 profile image
Lulu700 in reply to LeeLiam

I Take two twice daily with food . ✌️

Anyone considering taking this should be aware it's listed as an anti-coagulant.

Lulu700 profile image
Lulu700 in reply to bhayes84

Good for us on adt that are prone to coagulation .

Is that you Vinny Barbarino? Welcome back Carter! I’ve done Hono pure per my Nat onco for over six yrs clear and undetectable still . I like the nutrients given to me by a Nat dr . I take many others also . Good luck

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