I came across this article about research at Duke Medicine. I have come to believe the key to beating PCa is to cut off it's energy supply. The article backs that up while explaining why we end up mCRPC and gives alternative to ADT.
If this works we can kill the PCa without ADT torture, and survive mCRPC.
Now to figure out how to block this glutamine pathway. Would have been nice if the article had mentioned what the existing pharmacology was.
EDIT: We keep waiting on someone to create something and clinical trial it to handle this cancer when there are already proven natural substances that work.
Odd that we have to pay for access, considering that:
"The work received support from the Department of Defense (DOD-W81XWH-19-1-0411), the Prostate Cancer Foundation Movember Valor Challenge Award (2018), and the National Institutes of Health (K99- K99CA237618)."
I am old school, old farm stock. Grew up hearing "You get what you pay for." That holds true even more today when "it is all about money". I hope the D O D gets their money's worth when treating cancer is probably the V A's greatest expense treating veterans. It is expensive to do this research. If we who stand to benefit from work that might even save our lives pay a little for that information, seems only fair.
Finally there is a clinical trial going to happen. Yes a long road, maybe too long and too late for most of us................ clinicaltrials.gov/ct2/show...
In fact, after some deep digging, I found the 'equivalent' 'formula that achieves the same net effect.
The problem is the dosing, but the ingredients are listed.
I ordered 'a batch' from Amazon.
Here's what I found - the aim is to suppress glutamine.
A daily COMBO of Ursolic Acid, Trans-resveratrol and Turmeric extract is 'suggested' as the best approach. No 'single' sub-group offered much success, but the combo(s) offered more 'conclusive' results. There is still missing data - how long do you continue and how much do you take, but I will do ONE CAPSULE each and see how I feel - I'm hoping for no digestive upsets.
A quick Google question -> what suppresses glutamine ? and you'll get a list of about 10 chemical compounds.
KEEP digging and you'll find fuller explanations.
Ursolic acid comes from apple peels, trans-resveratrol from red grape skins and turmeric extract comes from the 'longo' sub-family root. [THIS]
I am combining [THIS] with my recently started bicalutamide monotherapy. I'll see the results, I'm assuming, in a few months as we monitor my PSA. I believe I'd have to cycle OFF the monotherapy to see if anything happened.
I'll report back at that time, unless I suspect that it has worked better / faster than expected, which will lead me to cycle OFF my monotherapy sooner. I assume 'd need to wait at least a month to even get HINT as to whether it was effective at all.
It MIGHT be worth a shot for some of us - maybe it will slow the cancer progression - maybe more, but thinking 'cure' is a stretch with OTC remedies.
SIMPLY use Google Search - use the words 'glutamine suppression' a LOT of 'stuff' appears - just 'ask questions' (search) and it will appear - keep digging and you'll find the 'components' that are in supplement form - that's how I found it and got what I wanted from Amazon.
Any news? How is your shade-tree oncology coming? After 4 months on my full off-label drug, plus the supplements and vitamins, and 3 months on chemo, docetaxel, I am having a much greater response than I would have expected from chemo alone. Pain from bone mets is gone in 4 weeks. PSA dropped from 69 to 9 in 6 weeks. Something is working.
Not expecting to see a response to an old post - but I will mention a supplement that I would HIGHLY recommend - from New Chapter - called Zyflamend - Herbal Joint Pain Reliever - it is much more than a 'joint formulation' - I take 2 a day in the morning with food. You'll get a 'bit' of aftertaste - from the ginger - but it has been one of the best / most significant supplements I've ever taken. It's not cheap, but worth the price IMO.
I'm also on bicalutamide monotherapy with great success - PSA almost undetectable after 3 months and still dropping - feeling well after original Dx over 4 years ago ......
"A daily COMBO of Ursolic Acid, Trans-resveratrol and Turmeric extract is 'suggested' as the best approach" "I am combining [THIS] with my recently started bicalutamide monotherapy. I'll see the results, I'm assuming, in a few months as we monitor my PSA. I believe I'd have to cycle OFF the "I was referring to our conversation here on supps to block glutamine. You are probably like me, with the combination of things we are doing it is impossible to know cause and effect. Somethings working for both of us. I came across this. Gives some information on dosing. From Jane McLelland.
If we suppress glutamine, do prostate cancer cells become immune to this eventually too? My question is do I try and suppress glutamine now while my father is hormone sensitive to treatment or wait until he’s castrate resistant ? Many thanks
The drugs and supplements I am taking compliment SOC treatments. It will not hurt to do everything you can to beat this cancer. It is not a matter of immunity. ADT blocks one metabolic pathway supplying the cancer. When you cut off one food source the cancer will find another. PCa metabolism is very complex. and it is more adaptable than roaches, even goes dumpster diving, salvaging material from dead cells. Cancers (all) main food is glucose. That is why the parasitic drugs are working for many (blocks glucose metabolic pathways). PCa favors fatty acids and glutamine, but will use what it can get. A D T treatment (hormone therapy) works until the cancer finds another path. You have to block all pathways, including continuing ADT I was on Lupron 3yrs, Abiraterone 1yr before adaptation. Some people make it a lot longer. Now I am mCRPC, so I have to block every pathway I can identify. In 02-2021 I started taking 5 off-label drugs and 7 supplements (after 2 yrs research). My oncologist agreed to script the drugs and monitor. And YES, you have to be very careful about what you take and what drugs don't mix, and especially read up on what the dr. gives you.
Get this book, How to Starve Cancer, Jane McLelland. It will explain a lot.
Hi there, thanks for your prompt response. Furthermore thanks for all info. Book is on order. Are those off label drugs and supplements unique to you? Many thanks
The drugs are the same ones COC is using. They picked up on what Jane was doing. The drugs and supplements are on her "metro map" . I verified what she was saying from at least two other sources. It is not one thing and/or another. It all works together. SOC, the off-label drugs and supps., plant based diet, and exercise. You have to do your own research. You can't believe me or anyone else on this internet. The ones you can consider are those who will site research.
Another GREAT source of information, all SCIENCE-BASED with studies provided (Scientific, not always Medical), and directed by Dr Michael Gregor, MD, is NUTRITIONFACTS.ORG. Here you can look up any compliment to Ronny's approaches -- all whole foods plant based foods that will work in concert with his approach. He outlines countless natural plant products that are toxic to cancer, from Cruciferous vegetables, to tomato products and curcumen.
If one combines Ronny's approach with EXERCISE (30 Min a day), and a WHOLE FOODS PLANT BASED DIET, stressing cancer killing vegetables, along with eliminating MEATS (Some Omega 3 rich Seafoods MAY be OK - Per Jane McLelland - pescatarian Diet for PC), and eliminating DAIRY (Dr T Colin Campbell PhD, Cornell University, says that caseine from milk products is the biggest trigger to grow cancer) and harmful OILS (Most vegetable except Extra Virgin Olive Oil, Avocado are inflammatory, pro-cancer), I've got to THINK that one might make some progress.
In addition to previous posts, adding FLAX SEEDS (Get WHOLE FLAX SEEDS, organic and grind them in a coffee grinder, eat within 15 min. (I add this to almond butter and cinnamon to make palatable), I'm reading AMAZING RESULTS from this alone (HEALINGGOURMET.COM and other sources).
Two other studies, one mentioned in Nutritionfacts.Org, is men were able to turn back PC remarkably in three weeks with 3/4 cup tomato sauce. Another study, (multiple sources), claimed that close to a cup of mushrooms a day had a powerful effect in diminishing cancer.
Dr. Dean Ornish, MD, also did a landmark study in 2008 where he followed 98 men with diagnosed prostate cancer. They were given a whole foods plant based diet (with none of the powerful agents mentioned here), and that alone was able to reverse cancer in most of the patients. The degree of success depended upon the degree of adherence to his plant based diet. All who adhered strictly were able to reverse it.
NOW -- add to Ronny's regimen these whole foods plant-based, the elimination of dairy, meats, toxic oils, and the addition of a whole foods plant based diet concentrating on those plants most toxic to cancer, the addition of FLAX SEEDS, and exercise, and I've got to think something has to happen to put a hurting on the cancer.
I am just starting out on my Hormone therapy treatment with Aberiterone. I wouldn't start messing with my medication just yet but fascinating that Glutamine is the source of 'food' for the cancer.
For others it has been seen as a helpful additional medication.
PCa metabolism is very complex. and it is more adaptable than roaches, even goes dumpster diving, salvaging material from dead cells. Cancers (all) main food is glucose. That is why the parasitic drugs are working for many (blocks glucose metabolic pathways). PCa favors fatty acids and glutamine, but will use what it can get. A D T treatment (hormone therapy) works until the cancer finds another path. I was on Lupron 3yrs, Abiraterone 1yr before adaptation. Some people make it a lot longer. Now I am mCRPC, so I have to block every pathway I can identify. In 02-2021 I started taking 5 off-label drugs and 7 supplements (after 2 yrs research). I am eager to get more information on RonnyBaby's post. My oncologist agreed to script the drugs and monitor. He will be getting this new information tomorrow. And YES, you have to be very careful about what you take and what drugs don't mix, and especially read up on what the dr. gives you.
I'm glad you found that. Obviously, the 'supplements' aren't the same as the new 'drug' BUT you can mimic it by using the combos that I mentioned.
It's the science that is the most encouraging and we must HOPE that this can move to TRIALS ASAP - this could be HUGE ....while hoping that Big Pharma doesn't push back and kill it in it's tracks !
John Hopkins quote: “By targeting glutamine metabolism, we were not only able to inhibit tumor growth and change the tumor microenvironment, but also alter the T cells in a way that we markedly enhanced immunotherapy for cancer," he says.
Although glutamine metabolism is a component of all cells of the body, the DON prodrug selectively targeted tumor cells because they are the "hungriest" for glutamine, said Powell. "What's emerging in metabolic therapy -- and to me this is why it's incredibly exciting -- is that a treatment like ours becomes selective because it preferentially affects the cells that have the greatest demand."
Thank you. This is the forth time I have seen these supplements evaluated. To put it in plain Okie (Okahoman, USA) ---curcumin (CUR), ursolic acid (UA), epigallocatechin-3-gallate (or EGCG), resveratrol (RES) ---Kick prostate cancers but.
After three years of searching, I believe blocking metabolic pathways is the best way to treat PCa. PCa is very resourceful. If one energy path is blocked (A D T) it finds another (glutamine, fatty acids, dumpster diving (salvage of material from dead cells, autophage). There is much information coming out recently from people looking at the metabolism of cancer, especially PCa, like Johns Hopkins and Duke Medicine. pnas.org/content/118/13/e20...scienceblog.com/.../new-the...
I am mCRPC. A D T no longer effective. S O C says "you are gona die". So I am going to be my own lab rat, conduct my own not clinical trials, and see if I live longer. No, it won't be proof metformin works, or any of the other off-label drugs I am taking work. If I am still alive in 5 years or even 2, will be enough proof for me.
Bud, like your response: Thank you. This is the forth time I have seen these supplements evaluated. To put it in plain Okie (Okahoman, USA) ---curcumin (CUR), ursolic acid (UA), epigallocatechin-3-gallate (or EGCG), resveratrol (RES) ---Kick prostate cancers but.
To give an update: When cancers become stage 4 often they have multiple fuel sources and metabolic pathways to feed the cancer. You have to starve the cancer, weaken it to give the protocol a chance. There are several ways to do this. One and probably most important is go on a strict plant based diet. There is an amino acid in food, methionine, that cancers thrive on, are addicted to, and is highest in meat, poultry including eggs, and dairy products. Two, there are off-label drugs and supplements that work to block different metabolic pathways. I got Jane McLelland's book, How to Starve Cancer, read it. I am taking most everything on her metro map. Through the research I did I convinced me and then my MO I knew what I was talking about. He scripted the meds, metformin, atorvastatin, and doxycycline. Already taking fenbendazole. and the supplements, 03-2021. 04-02-2021 PSA was 69. Started chemo, docetaxel, 04-18 . Something is working. 2 months, 2 rounds chemo, PSA is 9. Severe bone mets pain is gone (scan showed rt half pelvis solid black). Even the neuropathy in rt leg is improving. You an Okie too? OkC here.
Bud, thank you for sharing your research. PCa has a voracious appetite. It makes sense to me, to over feed it, then hit it. Have you been monitoring your 1 man Human Trial with blood work, PSA, Scans? Tall Allen would say be careful we do not treat the PSA, but its the Cancer we need to treat. Radiological scanning will show you how much progress you are making. Gosh wouldn’t it be amazing if you had real success ! If you wanted to be more scientific, you could make a visit to John Hopkins in Baltimore, and learn more, or possibly get into one of their studies?In any event, Man, best of luck for success.
My MO is monitoring, regular blood work with the chemo. On Medicare and social in- security, who can afford travel? Following Johns Hopkins close on the research.
Thanks Bud. Please keep us posted. No, not an Okie. Raised in Michigan (now in FL). But common sense goes a long way in my book, which you seem loaded with. With your start of Docetaxel, it will be hard to tell which component is making the most progress, but progress is progress. More power to you Bud. My best to you and yours,
After 4 months on my full off-label drug, plus the supplements and vitamins, and 3 months on chemo, docetaxel, I am having a much greater response than I would have expected from chemo alone. Pain from bone mets is gone in 4 weeks. PSA dropped from 69 to 9 in 6 weeks. Something is working. Will not know how well until a scan after chemo is done in Oct.
This DUKE University study follows the tenets of the PRESS PULSE study on the metabolic approach to Cancer posited by a study at GEORGE WASHINGTON University by Dr George Yu, MD, Dr. Thomas Seyfried,PhD from BOSTON COLLEGE. Their study also states, back in 2012, the key to suppressing cancer is exactly the same conclusion as the DUKE University study.
Incidentally, both studies follow the the broader tenets of Dr. Otto Warburg, whose nobel prize for Medicine in 1931 stated that cancer was a metabolic disease. The PRESS PULSE study reminds us that Dr Warburg's conclusions have never been dis-proven -- and in fact are followed by both the DUKE UNIVERSITY study and GEORGE WASHINGTON UNIVERSITY studeies. Go figure -- better yet, go see the PRESS PULSE Conclusions for yourself:
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