FYI:
jamanetwork.com/journals/ja...
Not sure I like the use of the term "virtual" prostatectomy. Several years ago something called a "brush biopsy" was promoted to dentists. IMO it was NOT a biopsy (though apparently the company was very aggressive in going after anyone who insisted it wasn't); it was cytology.
I don't like the nomenclature; still, if this holds up, it's great.
"while in the unfavorable category, the actuarial 4-year PSA relapse-free survival values were 75.0% vs 64.0% (HR, 0.76; 90% CI, 0.17-3.31) for SBRT vs SDRT, respectively." So given the equal toxicity, what is the advantage?
I'm very skeptical of no fractionation based on this:
prostatecancer.news/2017/01...
Well, yeah. I'm more than a little rusty on my medical statistics, but that's an awful wide confidence interval. Maybe no advantage, other than the convenience, and 4-year relapse-free survival ain't really enough.
You are right that it is statistically not different,but the sample was underpowered to detect a difference. Even if they are the same - I can't see any advantage - 5 10-minute treatments was really nothing, and the more mature, multi-institutional clinical data on HDR brachy and the radiobiology theory indicates a risk.
Interesting. But not quite ready for prime time.
Long-term adjuvant ADT improves results of brachy boost therapy in unfavorable-risk prostate cancer patients
"Pros and Cons of Various Forms of Radiation Therapy vs Radical Prostatectomy for Men in Their 50s"
Not All Prostate Biopsies Are Alike!
Partner of man with Gleeson 8 prostate cancer
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