From Subcutaneous to IV Actemra

[PMR2011]

Wondering if anybody has had to transition from subcutaneous Actemra to intravenous Actemra? I’m currently on weekly subcutaneous while tapering prednisone, (down to 10 mg) and will soon need to get IV infusions because of changes to insurance.

Were the side effects more pronounced with the IV? And how do you feel being “tethered” to the infusion center monthly?

Thank you everyone in the PMRGCA network for your support over the years!

[PMRpro Ambassador]

The GCA clinical trials were for the s/c injections so as far as I know, outside the USA only the injections are used. I have a suspicion that the weekly injections keep the receptors that it blocks better blocked, topping up the occupation of the new ones that are being created all the time. In the month between infusions, there are probably quite a lot left empty for the IL-6 to attach to and created inflammation.

But you are over a barrel when the fundholder says no aren't you?

[PMR2011 in reply to PMRpro]

Agreed, I suspect it will be a bit more of a roller coaster! Hope your vacation is going well!