How do you take your Prednisolone?

[InTheMoors]

My instructions on the medication just says 'take with food'. I split my dosage into three and take it with my meals. I assume that this is OK but should I be taking the dosage all at once?

[Koalajane]

hi, I was told to take mine all together with breakfast

[PMRpro Ambassador]

The recommendation is to take the entire dose at once in the morning, preferably with food. There are a few reasons for that but mostly because all the inflammation is created in the early morning at 4-4.30am and taking all the pred at once is the most efficient way of dealing with that. Another reason sometimes quoted is that that most closely follows the natural production of cortisol so means less adrenal suppression but that is less applicable to us as we take high enough doses for long enough to suppression cortisol production anyway, However, once we are below about 10mg it again becomes important so a single dose in the early morning creates the best conditions for the return of adrenal function - a level of pred in the blood at midnight that is as low as possible.

[InTheMoors in reply to PMRpro]

Thanks for the answers, I'm glad I asked. I was never told this. My morning dose of 8.5 mg is now ready!

If DL is reading this I got a pill cutter from Amazon, costing £3.99! I never knew such things existed.

[DorsetLady PMRGCAuk volunteer in reply to InTheMoors]

I am… and good shot…hope it helps 😊and agree with others, Pred taken in one dose is best.. certainly early days …and what is normally suggested.