Is this why MTX works for some and not for others?

[PMRpro]

Another interesting article from my inbox today! I'm sure you are all aware of the excitement about the gut microbiome and also that some people get a good result with MTX and others don't. Maybe the two are linked:

medscape.com/viewarticle/mo...

[Hoofprints]

That's really interesting. Your on fire today with the research - perhaps you should set up in business and teach the doctors!! Someone has to soon

[PMRCanada]

Thanks for sharing this. My recent reading of the book "A Silent Fire" helped me better grasp the terms used in this article.

I have been curious why I responded "favorably" to MTX, while others could not tolerate it. I guessed that perhaps I had another underlying autoimmune condition (other than PMR), but perhaps it is due to my gut microbiome??

[PMRpro Ambassador in reply to PMRCanada]

Or both. There is a lot unknown about most of this and it pays to be open-minded - as we know so many of our doctors aren't ...

[Sophiestree]

I was reading something very similar yesterday about gut biome and RA.

[PMRpro Ambassador in reply to Sophiestree]

Same work probably - the MTX study was in RA patients.

[sidra1968]

Great find, thank you

[cherrysteps]

I have no experience of methotrexate

[CathyMeg]

thank you very interesting. Followed up on butyrate and came back to basically the Mediterranean diet. ! Fiber rich and well hydrated confirmed. Very glad to see the medical profession looking more into gut health.

[LemonZest11]

Great read, thank you. That Clifton O. Bingham 111 gets around!