Vomiting migraine and pred

[Clucket]

My migraines which involve vomiting seem to be returning. If I only take enteric coated pred with no food, how long have I got for it to have gone through my stomach before the vomiting brings it up? I was originally given an anti emetic tablet which now has no effect.

[Sillydogsmum]

If you took some Paracetamol at the same time as your Pred would it head off the migraine if you think one might be brewing? I find it works if I want to be certain of not having one at an unimportune moment. Enteric pred probably more likely to go through the stomach quicker with food than without.

[Clucket in reply to Sillydogsmum]

Paracetamol has never stopped the migraines. Food or even water seems to increase the likelyhood of being sick sooner, but even with no food or drink i just retch up bile. So was hoping for a guide as to how long it may be likely it has gone through my stomach.

[Clucket in reply to Sillydogsmum]

Paracetamol has never stopped the migraines. Food or even water seems to increase the likelyhood of being sick sooner, but even with no food or drink i just retch up bile. So was hoping for a guide as to how long it may be likely it has gone through my stomach.

[PMRpro Ambassador in reply to Clucket]

It is thought to be 3 to 4 hours at least before e/c is broken down in the lower gut and absorbed. Plain pred is about an hour.

[PMRpro Ambassador in reply to Sillydogsmum]

No - other way round. If you have food, the gastric emptying is delayed.

[Sillydogsmum]

So do you always get your migraines after the Pred? I'm maybe being a bit dim but if your migraines come on any old time during the day , could you not take the Pred early first thing in the morning with some yoghurt or an early breakfast?I would have thought that 2 hours would see the Pred out of your stomach.

medlineplus.gov/lab-tests/g...

My higher dose has definitely increased my migraines.

[Clucket in reply to Sillydogsmum]

They start early in the morning and the last one lasted all day. I was wondering how long I had if I took the pred very early before I was sick, of j took enteric coated I wouldn't have to eat so it may hold the vomiting off for longer

[Clucket in reply to Sillydogsmum]

Eating or drinking seems to make me vomit hence enteric coated so i don't have to eat. Wondered how long till it left the stomach as i can't tell if its gone through or not

[Sillydogsmum]

Do you take a Triptan? Have you tried B blocker as a preventer? Migraines are a real nuisance when they come on too often and last a long time.

[Clucket]

I don't take a Triptan. When I saw the Dr this was never suggested. I was just given an anti emetic which now doesn't work

[Sophiestree in reply to Clucket]

I am similar to you with migraines in that a tiny sip of water would set me off or just moving my head half an inch. I am prescribed Ondansetron wafers that dissolve on your tongue. Sometimes I need two and then try and sleep off the awful feeling of retching all the time. My stomach used to be covered in small burst blood vessels from all the straining. I couldn't take anti sick pills as I couldn't keep them down, hence the wafers. They are expensive and so I ration them and don't get them on every repeat prescription.

[Clucket in reply to Sophiestree]

Thanks everyone. I will try and get something else prescribed that works.

[Sillydogsmum]

migrainetrust.org/live-with...

There are quite a lot of treatment options, depends what might work for you. You shouldn't have to put up with lots of migraines and vomiting, especially if it risks you losing your Pred and messing up your PMR. There's loads of great info on this site.

[agingfeminist]

This is awful. You need much better support from your doctor...please be in touch with your doc...

how often does this happen? you need to be trying different medication...the risk of getting dehyrated through continuous vomiting is not going to help you or your migraine,

[AtopicGuy]

Prednisolone is available (in the UK NHS) as a liquid. Perhaps that would help? Liquids spread out immediately in the stomach and so are less likely to 'burn' one spot on the stomach wall like a pill. This may also speed up absorption.

"In humans, the pharmacokinetics of prednisolone is complex. After oral intake, it exhibits rapid absorption and becomes almost completely (80%-100%) available. Peak plasma concentrations reach 1 to 2 hours after oral administration." See 3rd paragraph of the introduction to: ncbi.nlm.nih.gov/pmc/articl... which is about pills, not liquids.

[PMRpro Ambassador in reply to AtopicGuy]

They are usually on a restricted list since liquid pred costs approx, thirty times what plain pred does.

[AtopicGuy in reply to PMRpro]

I'm not surprised. But if anything qualifies for spending a little more, surely "migraines which involve vomiting" meets the criterion. It sounds hellish. The worst I've had felt like an axe to the skull, which was bad enough.

[PMRpro Ambassador in reply to AtopicGuy]

Not how it all works unfortunately ...

[AtopicGuy]

I once attended A&E (UK NHS for ER) with a minor injury and, after being patched up, was sent home with a litre of liquid paracetamol, despite telling the doctor I had plenty of paracetamol pills at home! She insisted I take it, saying they were "out of tablets, at the moment".