Maybe more knowledgeable folks will say otherwise, but when I was on Lanoprazole, I just took it once a day and didn't think about any other circumstances. I took it for almost two years and now I am on sulcralfate. Hope it helps, take care❤️
It doesn't "line the stomach" - it reduces the production of gastric acid and the effect lasts for much of the day. It works best taken on an empty stomach half an hour before food.
Taking pred with or after food works on the "lining the stomach" concept - there is something there to give the gastric acid something else to work on if you want to look at it that way.
Many on the forum only take the pred with or soon after food - and it works fine for them, especially at lower doses. Others struggle without a PPI whatever the dose.
I was thinking that I was perhaps eating unnecessary food but I should, as you say, continue what I am doing: Lansoprazole, wait at least 30 minutes, food, pred.
Don't worry about eating more than you want- many patients manage on just a portion of yoghurt but it is a good idea to have something there so the mechanical irritation of the pred tablets as they dissolve in the stomach is reduce. In the UK the alternative is to use enteric coated pred wbich pass through the stomach before being broken down - avoiding the problem.
I have been considering moving my prednisolone dose to very early morning (c.02.00 as I have read others do in this forum) as I am a 'night owl'.
Bearing in mind your comment above regarding enteric coated pred passing through the stomach before being broken down, I am now wondering if this would suit such a dosing schedule (and additionally, I would not need extra food..... a bonus). I understand that cytokines are released around 04.00.
I am about to request a further supply of prednisolone from my GP and am unsure if I should request the enteric coated version. Could I please ask for your thoughts?
Not weighing in on enteric-coated pred. Only in the UK I'm told - lucky you! However, you have been told, I hope, that PPIs can affect bone density when taken longterm as they interfere with absorption of a number of nutrients, including calcium? ( Incidentally, I'm one of those who have switched to the early morning dosing and finding it works well for me. I take it with about 1/3 c of plain 2% or 3.5% yoghurt.)
I talked to Dr Sarah Mackie about that - there is a form of pred you take at 10pm which has a delayed release for 2am but it isn't funded in the UK as it is pretty expensive. We wondered about taking e/c pred before bed and she agreed it would work - in fact there are several people on the forum who do it.
Apparently someone wanted to to a comparison between e/c and the delayed release format but the d/r company weren't interested. We suspect because they realised that e/c was a lot cheaper way to achieve a similar effect!
Thank you very much for your reply - I knew I could pick your brains!
I have requested enteric-coated prednisolone from my GP and wait to see if they will prescribe it.
Your tale of the delayed release company not wanting to undertake head to head trials with an enteric-coated formula was rather interesting - and telling!
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Before Prednisolone
Is it absolutely necessary to take omeprazole before Prednisolone? 
Bowel upset on Lansoprazole 
Omeprazole/Lansoprazole
