Lansoprazole and/Or Food Before Prednisolone?

[Rostom]

I would be grateful if someone could please advise....

I have been prescribed Lansoprazole (to protect my stomach from prednisolone) to be taken 30-60 minutes before Prednisolone.

The instructions with the prednisolone say to take it after food.

I have been doing both, i.e. (Lansoprazole followed later by food, then the Prednisolone).

Have I made a mistake and should be taking a Lanoprazole, then 30 to 60 minutes later the Prednisone?

In other words, the food is unnecessary as the Lanoprazole acts in the way that the food does, lining the stomach?

[Grammy80]

Maybe more knowledgeable folks will say otherwise, but when I was on Lanoprazole, I just took it once a day and didn't think about any other circumstances. I took it for almost two years and now I am on sulcralfate. Hope it helps, take care❤️

[Rostom in reply to Grammy80]

Thank you for your reply, Grammy 80.

[cmToddy]

Hi there. I take Preds and Lanzaprasole straight after breakfast with no problems for over two years. Good luck

[Rostom in reply to cmToddy]

Hi Seacat. Yes, I have been doing what you are but just wondered if I really needed the food. I do, so will carry on carrying on!

Many thanks.

[Seacat30]

I used to take Lansoprazole then wait 30 minutes for breakfast and take the prednisolone in between bites of food.

[Rostom in reply to Seacat30]

Hello Seacat30As above(!) I do what you do and will continue. Apologies for the name mix up above and many thanks for your reply!

[Telian]

Exactly as Seacat30 says. Lansoprazole 30 mins before pred. Take pred with food.

[Rostom in reply to Telian]

Hi TelianI will continue to do as you are doing. Thanks for your reply.

[PMRpro Ambassador]

It doesn't "line the stomach" - it reduces the production of gastric acid and the effect lasts for much of the day. It works best taken on an empty stomach half an hour before food.

Taking pred with or after food works on the "lining the stomach" concept - there is something there to give the gastric acid something else to work on if you want to look at it that way.

Many on the forum only take the pred with or soon after food - and it works fine for them, especially at lower doses. Others struggle without a PPI whatever the dose.

[Rostom in reply to PMRpro]

Thank you PROpro for sorting me out!

I was thinking that I was perhaps eating unnecessary food but I should, as you say, continue what I am doing: Lansoprazole, wait at least 30 minutes, food, pred.

I seem OK with the Lansoprazole so will carry on.

Many thanks.

[PMRpro Ambassador in reply to Rostom]

Don't worry about eating more than you want- many patients manage on just a portion of yoghurt but it is a good idea to have something there so the mechanical irritation of the pred tablets as they dissolve in the stomach is reduce. In the UK the alternative is to use enteric coated pred wbich pass through the stomach before being broken down - avoiding the problem.

[Rostom in reply to PMRpro]

Hello again

Thank you PMRpro for your reply to my question.

I have been considering moving my prednisolone dose to very early morning (c.02.00 as I have read others do in this forum) as I am a 'night owl'.

Bearing in mind your comment above regarding enteric coated pred passing through the stomach before being broken down, I am now wondering if this would suit such a dosing schedule (and additionally, I would not need extra food..... a bonus). I understand that cytokines are released around 04.00.

I am about to request a further supply of prednisolone from my GP and am unsure if I should request the enteric coated version. Could I please ask for your thoughts?

Many thanks

[HeronNS in reply to Rostom]

Not weighing in on enteric-coated pred. Only in the UK I'm told - lucky you! However, you have been told, I hope, that PPIs can affect bone density when taken longterm as they interfere with absorption of a number of nutrients, including calcium? ( Incidentally, I'm one of those who have switched to the early morning dosing and finding it works well for me. I take it with about 1/3 c of plain 2% or 3.5% yoghurt.)

[PMRpro Ambassador in reply to Rostom]

I talked to Dr Sarah Mackie about that - there is a form of pred you take at 10pm which has a delayed release for 2am but it isn't funded in the UK as it is pretty expensive. We wondered about taking e/c pred before bed and she agreed it would work - in fact there are several people on the forum who do it.

Apparently someone wanted to to a comparison between e/c and the delayed release format but the d/r company weren't interested. We suspect because they realised that e/c was a lot cheaper way to achieve a similar effect!

[Rostom in reply to PMRpro]

Thank you very much for your reply - I knew I could pick your brains!

I have requested enteric-coated prednisolone from my GP and wait to see if they will prescribe it.

Your tale of the delayed release company not wanting to undertake head to head trials with an enteric-coated formula was rather interesting - and telling!

Thank you again.

Regards

[Suffererc]

I took Lanzaprole 30 minutes befor taking Pred then Breakfast

[Howardd]

Your approach seems fine, as you've been taking lansoprazole, waiting, then eating before prednisolone. Lansoprazole protects your stomach by reducing acid, not by "lining" it, so food isn't strictly necessary to perform its role. However, eating before prednisolone is generally recommended to help minimize irritation to the stomach lining, particularly if you're prone to discomfort.

Personally, I take prednisolone myself and find it works excellently. I order from this reliable pharmacy - global-world-delivery.com/c..., the quality and effect are always great. I always follow it with food as suggested, even when using a proton pump inhibitor like lansoprazole. If you're unsure or experiencing side effects, discussing it with your doctor or pharmacist is the safest course.

[PMRpro Ambassador in reply to Howardd]

This post is 3 years old!!