I have just been "officially" diagnosed with stage 2 PBC this week and started Ursodiol tonight. Does anyone know how long it takes until it begins to help? I know the fatique will probably not go away, but I have liver, hip, and back pain along with itchyness and hope these symptoms will lessen. I wish the fatigue would go away. My GI Doctor prescribed 300mg three times a day. Does anyone take it twice a day? I work 3 night shifts a week and cant see how I can take it the same time every day - I REALLY dont want to set my alarm while I am sleeping to take my medication.