Hi! I'm new to this group & was dx'd with PBC in April 12. I have been dealing with joint pain...fingers, knees etc. I don't have RA my Dr thinks its just the PBC. I have been taking 2 Ursodiol pills daily but my dr has bumped ne up to 3 500 mg pills a day. Dr thinks cause my alka phos is still in the 200s taking more urso will help. My hands & wrists are breaking out with little blisters and they itch like crazy. Has anyone had this happen...is it a reaction to more urso? I had no itching prior to taking this 3rd pill.