I have PBC and another auto-imune condition. I am having a fairly stressful time at the moment - quite unexpectedly, and outside my control. My main PBC symptom has been fatigue. I have had very slight itching, but nothing worth worrying about. However, the itching is now getting much worse. If it's just the symtom being exacerbated by stress, then I'll cope with it, but my question is: whether stress can cause the effect of PBC on the liver to worsen.