I have been taking urso for 10years and after reaching the end of my tether with the horrendous itch I decided to stop taking the urso to see if I would feel any different. I based my decision on my blood results over the last 11 yrs which is when I first took the itch amongst other symptoms. There have been no significant changes in my lft readings from then until now so I felt the tablets cant be helping ( I have never had normal lfts in 11 yrs) and felt the urso could actually be contributing to the itch. My itch is much more tolerable since stopping them and I informed my hepatologist of what I had done and he did not mind in the slightest! I thought I would have been given a lecture on stopping them! Over the past year I have been tried on various drugs to alleviate the itch as it had become really unbearable but none of them worked. The questran did and does still help but I can't believe the difference with the itch since stopping the urso! I still have to go for transplant assessment as had been referred due to intractible itch and as still have it but to a lesser degree so will be interested to see what shape my liver is in and will quiz the top specialists as to the use of urso in pbc and if maybe my stopping it is the right thing to do. Will keep u all posted!