I am someone with Scleroderma (anti centromere antibody +ve) which is a pretty horrible condition. With it comes fatigue, very dry eyes etc etc. I am however highly positive for anti mitochondrial antibody and occasionally (!) anti smooth muscle antibody. My LFT's are ok, but i suffer from alot of PBC symptoms, but which could also be Scleroderma related. I have a lot of inflammation in my bloods and am Vit D deficient. Just wondering if anybody else has these sort of issues, and whether anti mitochondrial antibody means you defo have PBC?