Anyone with elevated eosinophils?

[Liverette]

It’s been few years that my eosinophils are always elevated, around 13 and normal range is (0-5). My doctor says it is allergies, but I keep reading that allergies don’t cause that high of a range. I was wondering if PBC is the cause and if other PBCers have had elevated eosinophils.

[gwillistexas]

Mine is bottom of normal.

[Hidden in reply to gwillistexas]

Mine too

[Liverette in reply to Hidden]

Jenny, are your eosinophils elevated too or at the bottom of normal?

[Hidden in reply to Liverette]

Mines the bottom of normal

[gwillistexas]

Have you also looked at your BASO%?

[Liverette in reply to gwillistexas]

The rest of the blood test results are in normal range, including basophils.

[gwillistexas in reply to Liverette]

That’s good👍

[claygi]

In the past , I have had elevated eosinophils, yes.

[June9961]

Yes mine are just over the range. Baso is in the low range.

[ritarobainapbc]

Yes, I have had high eosinophils for many years before I was diagnosed with PBC . The eosinophils were high as well as GGT

[Gjt777]

Hi Liverette. My eosinophils were elevated for about a year and a half before diagnosis and they didn't come down until I started taking ursodiol. My hematologist sent me this as I was being worked up for all kinds of things at the time.

I think the eosinophils are a secondary issue, not a primary bone marrow disorder. I see you are being evaluated for adrenal insufficiency that can do this. Can also be caused by primary biliary cirrhosis alone- see article below:

Eosinophilia in primary biliary cirrhosis.

Yamazaki K1, Nakadate I, Suzuki K, Sato S, Masuda T.

Author information

Abstract

OBJECTIVES:

Recent studies have shown the occurrence of eosinophilia in patients with primary biliary cirrhosis (PBC). To examine whether eosinophilia is indeed a distinctive feature of PBC, we performed extensive leukocyte differential analysis using a highly sophisticated hematology instrument. We also investigated the relationship between eosinophil dynamics and clinical features of PBC including the effects of ursodeoxycholic acid (UDCA) treatment.

METHODS:

A flow cytometry-based blood cell analyzer (Technicon H6000) was used to examine peripheral blood eosinophil counts in 38 patients with PBC and 131 patients with various liver deseases. We also performed eosinophil quantitation in 19 PBC patients before and after administration of UDCA for 4 wk.

RESULTS:

Patients with PBC had significantly higher relative and absolute eosinophil counts when compared with other liver diseases (5.7 +/- 0.5% [p < 0.0001, mean +/- SEM] and 312 +/- 26 cells/microliter [p < 0.01], respectively). Twenty-one of 38 PBC patients (55%) exhibited relative eosinophilia. In patients with PBC, the eosinophil count was: 1) significantly higher in those with early histological stages (stage I-II, 6.5 +/- 0.5% vs stage III-IV, 4.4 +/- 0.7%,p < 0.05), 2) positively correlated with basophil count (p < 0.01), serum IgA levels (p < 0.05), and the degree of eosinophil infiltration in the portal tract (p < 0.01), and 3) markedly reduced by UDCA treatment (before: 5.9 +/- 0.7%, 307 +/- 37 cells/microliter; after: 2.8 +/- 0.03% [p < 0.001], 162 +/- 26 cells/microliter ¿p < 0.001]).

CONCLUSIONS:

Eosinophilia is a common and distinctive feature of patients with PBC. UDCA ameliorates eosinophilia as well as liver function tests in PBC patients. Eosinophilia may be useful as one of the initial clues in the diagnosis of PBC, especially in its early stage.

I hope this helps put your mind at ease.

Best wishes,

Gloria

[Liverette]

Thank you all for your replies.