Anyone with elevated eosinophils? - PBC Foundation

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Anyone with elevated eosinophils?

Liverette profile image
12 Replies

It’s been few years that my eosinophils are always elevated, around 13 and normal range is (0-5). My doctor says it is allergies, but I keep reading that allergies don’t cause that high of a range. I was wondering if PBC is the cause and if other PBCers have had elevated eosinophils.

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Liverette profile image
Liverette
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12 Replies
gwillistexas profile image
gwillistexas

Mine is bottom of normal.

in reply to gwillistexas

Mine too

Liverette profile image
Liverette in reply to

Jenny, are your eosinophils elevated too or at the bottom of normal?

in reply to Liverette

Mines the bottom of normal

gwillistexas profile image
gwillistexas

Have you also looked at your BASO%?

Liverette profile image
Liverette in reply to gwillistexas

The rest of the blood test results are in normal range, including basophils.

gwillistexas profile image
gwillistexas in reply to Liverette

That’s good👍

claygi profile image
claygi

In the past , I have had elevated eosinophils, yes.

June9961 profile image
June9961

Yes mine are just over the range. Baso is in the low range.

ritarobainapbc profile image
ritarobainapbc

Yes, I have had high eosinophils for many years before I was diagnosed with PBC . The eosinophils were high as well as GGT

Gjt777 profile image
Gjt777

Hi Liverette. My eosinophils were elevated for about a year and a half before diagnosis and they didn't come down until I started taking ursodiol. My hematologist sent me this as I was being worked up for all kinds of things at the time.

I think the eosinophils are a secondary issue, not a primary bone marrow disorder. I see you are being evaluated for adrenal insufficiency that can do this. Can also be caused by primary biliary cirrhosis alone- see article below:

Eosinophilia in primary biliary cirrhosis.

Yamazaki K1, Nakadate I, Suzuki K, Sato S, Masuda T.

Author information

Abstract

OBJECTIVES:

Recent studies have shown the occurrence of eosinophilia in patients with primary biliary cirrhosis (PBC). To examine whether eosinophilia is indeed a distinctive feature of PBC, we performed extensive leukocyte differential analysis using a highly sophisticated hematology instrument. We also investigated the relationship between eosinophil dynamics and clinical features of PBC including the effects of ursodeoxycholic acid (UDCA) treatment.

METHODS:

A flow cytometry-based blood cell analyzer (Technicon H6000) was used to examine peripheral blood eosinophil counts in 38 patients with PBC and 131 patients with various liver deseases. We also performed eosinophil quantitation in 19 PBC patients before and after administration of UDCA for 4 wk.

RESULTS:

Patients with PBC had significantly higher relative and absolute eosinophil counts when compared with other liver diseases (5.7 +/- 0.5% [p < 0.0001, mean +/- SEM] and 312 +/- 26 cells/microliter [p < 0.01], respectively). Twenty-one of 38 PBC patients (55%) exhibited relative eosinophilia. In patients with PBC, the eosinophil count was: 1) significantly higher in those with early histological stages (stage I-II, 6.5 +/- 0.5% vs stage III-IV, 4.4 +/- 0.7%,p < 0.05), 2) positively correlated with basophil count (p < 0.01), serum IgA levels (p < 0.05), and the degree of eosinophil infiltration in the portal tract (p < 0.01), and 3) markedly reduced by UDCA treatment (before: 5.9 +/- 0.7%, 307 +/- 37 cells/microliter; after: 2.8 +/- 0.03% [p < 0.001], 162 +/- 26 cells/microliter ¿p < 0.001]).

CONCLUSIONS:

Eosinophilia is a common and distinctive feature of patients with PBC. UDCA ameliorates eosinophilia as well as liver function tests in PBC patients. Eosinophilia may be useful as one of the initial clues in the diagnosis of PBC, especially in its early stage.

I hope this helps put your mind at ease.

Best wishes,

Gloria

Liverette profile image
Liverette

Thank you all for your replies.

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