Hi All! Recently diagnosed and from my research of PBC, I am apparently the rarest of the rare- a male diagnosed with PBC and AMA-negative. I am headed to Mayo in a couple of weeks for a second opinion. Was diagnosed based on biopsy (very mild scarring) and high Alkaline Phosphatase. I have no symptoms and was started on Ursodial (no complications in the first three months). Guess we shall see what Mayo has to say. The PBC Foundation has a lot of great information!