I'm so glad to find this board...everything I read on the internet about PBC takes my breath away. Here's my story: I am immune deficient - I have CVID, Common Variable Immune Deficiency. I do immune replacement therapy every week via subcutaneous infusion. My lft's have been abnormal for months and I had lots of gallbladder pain. They removed my gallbladder on Tuesday and did a liver biopsy at the same time. (This recovery is no fun, by the way...with immune deficiency I have lots of other infections to deal with.) As of last week, my GGT is 165, ALP is 338, and AMA is 158. My bilirubin is normal.Also, my IgM levels have been creeping up. I can't imagine that I DON'T have PBC...but would love your thoughts. I'm already grateful for your help!