Does anyone else have a problem with these or am I unusually sensitive to them? In march of last year I was active,going to the Gym 3x weekly and a dance class.As a result of discovering i was stage 4 with portal hypertension and varices. I was put on Propanolol and within 2 months progressively withdrew from my classes and felt as if I were trying to swim in deep wateragainst a strong current. Even my speech and thought processes became dampened-almost like a major tranquilliser effect. I persevered untill October , had 3 weeks 'off' in which I could walk and think unimpeded, then commenced on Carvedilol. My varices were treated (oesophageal). Over a period of time I found increasing difficulty with mobility as a result of breathing problems. I have had mild COPD for some years but it has not affected me previously., I becam exhausted climbing the stairs and my heart was pounding on reaching the top. My walks in the hills and on the coast path dissapeared completely and I felt as if I had become an invalid. Every thing was an effort. . In June whilst away from home I halved the carvedilol (i.e. 6.25mgs once instead of 2x daily) After 2 weeks I felt no differnce. After a few days on half again of that dose I gave them up entirely. Within days I was on the coast path walking at a normal pace without stopping every few steps and gasping for breath. I understand that varices can occur anywhere in the body, can ruptur and often be fatal. As an ex nurse I have seen this occur and have lived in dread of this happening for the last 20 years since diagnosis of PBC. Does anyone know of an alternative?