Help please

[tdave]

Hi there! I Was diagnosed in 2010 with PBC via biopsy and positive AMA. At that time my ANA was negative, it is now positive and I actually have normal LFTS which I did not have in 2010. Is anyone familiar with P80 coilin? It was listed next to my ANA results. Thanx!

[spoul]

Not familiar with this .......are you in the UK?

[Keren]

Hi tdave,

This might help: medscape.com/viewarticle/51... - there's a paragraph referencing p80 coilin:

"Autoantibodies are generally believed to present a hallmark for the diagnosis of AIH, but up to 20% of patients with AIH present without ANA, ASMA, or LKM1.[10] ANAs represent the least specific serum autoantibodies for the diagnosis of chronic liver diseases and are also found in up to 30% of elderly healthy controls, up to 10% of pregnant women, and up to 30% of patients with malignancies.[48] ANAs in the serum of patients with PBC are not a marker of AIH-PBC overlap syndrome, but are found at considerable rates in PBC patients without any further signs of AIH. In contrast, ANAs with a specific immunofluorescence pattern of multiple nuclear dots directed against Sp100 (five to 10 dots) or Coilin p80 (two to six dots) are rather specific although less sensitive for PBC.[48] In a small subgroup (3.9%) of 233 patients with PBC, the presence of SLA autoantibodies was a marker of AIH-PBC overlap syndrome with a good response to immunosuppressive therapy.[49]"

So it looks like it's a marker specific to PBC.

[Hidden]

Hello, well I try not to look too much into certain things out on the net but I haven't heard of this P80 coilin in any context nor on this site previously.

I Googled and as I am in the UK I only looked up as such. On the Birmingham Uni site I found a table which lists ANAs. I know I had the ANA check along with the AMA and to my knowledge some others which I have no idea of as I never asked. I only know about the ANA as when the consultant took the AMA he wrote on is letter to the GP (I got a copy off my GP) the results of both (my ANA was negative) when he diagnosed me with PBC Dec 2010. I had no biopsy.

I noticed the AMA check is on the table and that states that PBC could be the association with it. Apparently as far as I understand from the info is that P80 coilin is connected with ANAs so it might be a standard check and for all I know at some point in my early days just prior to being diagnosed with PBC or even just after I might have had this check too. I have posted the link but I'd not really look too much into it myself. I'd ask you doctor about it so you have a more accurate explanation.

birmingham.ac.uk/facilities...