My wife has been jaundiced for 2 weeks and itching for 2 weeks prior to that, at the commencement of yellowing she was hospitalised for a week for observation and tests as of which have proved inconclusive. The itching and burning are causing massive discomfort along with lack of sleep, the doctors are unwilling to prescribe questran for reasons unknown to us , and a general lack of information and general shrugging of shoulders is driving us mad. This is on top of all the other distressing symptoms of hepatitis/pbc of which you are all aware, as we have no diagnosis we can`t say which. Some of the other symptoms would be more bearable if we could see an end to the dreaded itching. So can anyone please give us a timescale of what to expect , Thank you very much any info both pessimistic and optermistic gratefully received.