Hi I keep reading on here lots of comments that here in the uk they tend not to do biopsys for diagnosis. Not true. It all depends where you are. I have high AMA's & ana's and they are still insisting that I have one for diagnosis. Even though I've been on urso since March. I've refused two thus far & they are getting angry with me. I can also ( & have when they listen) ticked the box to lots of the other symptoms on the list. So on my illnesses summary letter. It is still marked as possible PBC. I don't want the horrible thing. I've had 8 ops (for another condition) in the last 6 years the last one of which went wrong and caused a 6 month recovery instead of 6 weeks. So I am very reluctant to have anything else for what ever reason done. Has anyone any advice on how I can get over this hurdle either practically or mentally? X TB.