I found out I have PBC about 5 months ago. I started on the URSO and the first month I didn't notice any difference but the end of the second month to the beginning of the 4th month I was feeling really great. I didn't have any pain,my, blood work was just about normal and I actually had energy. then, almost over night I felt awful again. My hips, hands, shoulders, and feet ache so bad I can hardly walk, I am taking 4 to 5 Vicodin daily and it is just barely helping, I am sleeping all the time, and I am itching again. I also am getting right side/liver pain. I go for my second appt with the GI specialist on the 29th. Has this happened to anyone? I am taking 300 mg of URSO three times a day. Do you think I will need to up the dose? Should I call my doctor? I was so hoping the URSO would work for me. Sigh.