B12 injection impact on test results

[Rosydawn]

Hello …. FYI

After struggling with my own test results for cholesterol etc I was reminded of this data sheet for B12 injections which I came across as a result of a visit to New Zealand.

It is worth looking at for anyone who is receiving hydroxycobalamin injections and being investigated for other ailments. It is at medsafe.govt.nz . Google: New Zealand data sheet hydroxycobalamin …. sorry I’m not tech enough to send it as a link.

It is the New Zealand version of the panpharma b12 injection data sheet and has a lot more information on it than the uk version. It highlights a number of routine medical tests that may be interfered with, the how and why as well as a statement on long term injections when there is a renal impairment. Worth a read for those who are self advocating.

Hope it helps somebody

[Technoid]

"The administration of hydroxocobalamin may affect various clinical chemistry laboratory

tests due to its characteristic of absorbing light. The chief laboratory tests that may be

affected by the administration of hydroxocobalamin are those that involve the use of

colorimetric methods or that require the use of Nicotinamide Adenine Dinucleotide

(NAD) and Nicotinamide Adenine Dinucleotide Phosphate (NADP).

An artifactual increase has been observed in the levels of creatinine, bilirubin,

triglycerides, cholesterol, total proteins, glucose, albumin and alkaline phosphatase and a

decrease in alanine aminotransferase (ALT) and amylase. Unpredictable results have been

observed in the levels of phosphatase, uric acid, aspartate aminotransferase (AST),

creatine phosphokinase (CPK), creatine phosphokinase isoenzymes (CK-MB) and lactate

dehydrogenase (LDH). "

medsafe.govt.nz/profs/datas...

I would be careful with assuming that a cholesterol result is artifactual unless the lab actually confirm that to you explicitly, it seems like it will depend on the test used. As usual FlipperTD may have some insights.

[Nackapan in reply to Technoid]

Thank you . I was struggling to understand the information

Artifactual? Not familiar of the use in this context or word actually.

I thought it does not mean artificial or perhaps does in medical terms ?

[Myoldcat in reply to Nackapan]

I googled it... when used in medical imaging or laboratory testing it means "apparently but not truly"

[FlipperTD in reply to Nackapan]

The term is 'artefactual', as in 'an artefact'. So, something made by humans, such as a flint arrowhead. Not something 'naturally occurring'. Someone who consumes a lot of beetroot may pass red-coloured urine. That can be mistaken for bleeding [although it's a different colour!] but it's an artefact.

[FlipperTD in reply to Technoid]

It's worth noting that a lot of the results we produce may be susceptible to interference by a range of extraneous substances, but I suspect that the list above shows extreme cases.

'Blank' tests may be performed in some cases to demonstrate the presence of interfering substances. Sorry I can't be more specific!

[Nackapan in reply to FlipperTD]

Helpful .Thank you.

Yes I'm more than aware of the red urine after homegrown beetroot most of my life .

My husband wasn't and didn't say a thing thinking he was ill!!!

Until I mentioned it .

[Rosydawn in reply to Technoid]

Thanks Technoid for putting the link in. I am so rubbish.

The other thing I noted on the data sheet was the stated potential for long term impact of aluminium toxicity if the kidneys are not functioning well. This is the first and only thing I have seen referenced on long term impact of b12 injections.

Has anyone got a view on this? We don’t have a choice about the injections and I know my kidneys aren’t 100% according to my GP but we haven’t done anything further work on it because it is borderline. Should I be worried?

[Sea-blue]

My kidneys aren’t functioning that great at the moment Rosydawn. I’m interested in comments about this too

[Fluffyfloo]

This has raised a number of questions for me:

1) Why does it have aluminum, and does Pascoe brand have aluminum in it too?

2) How does it affect your folic acid levels?

3) Why should it not be used in people with megaloblastic anemia or in women who are pregnant?

[Rosydawn in reply to Fluffyfloo]

Fluffyfloo, Sorry I can’t help you on your queries and I am not a medical person

I personally don’t suppose for one minute there is aluminium in any of the B12 injections so don’t worry about that. I think the aluminium aspect is linked to the poor function of the kidneys, so my guess is that because of the body chemistry of the B12 and kidneys cycles, aluminium may not be excreted quite as well as other materials the kidneys clear over a long period of time.

I personally won’t be changing anything just now.

[Fluffyfloo]

Several years ago I looked up the brand of cyanocobalamin ampules that the local pharmacy carried, and they did have aluminum as an ingredient, as I recall. I can't imagine why aluminum should ever be in B12.