Good that the article has been published - but they should not have missed the different forms of B6 which might be very important.
Simon never linked the pain in his hands and feet to multivitamins – but a pathology test didA growing number of consumers are presenting with symptoms linked to high levels of vitamin B6, pathologists say, while the supplement industry goes unpoliced
"PLP-based supplements are preferred over pyridoxine supplements because of minimal neurotoxicity observed in neuronal cell viability tests. Since B6 metabolites have a long half-life, weekly administration is preferred over daily use to prevent toxicity."
Informative as ever, thank you. I have just dug out my B6 supplement (Nutri-meds) and am relieved to find that it is not the dodgy, inactive form pyridoxine, but the active pyridoxal-5-phoshate 25mg. I am taking it to lower my homocysteine levels. I haven't had any symptoms of over dose. Having said that, as the tablet is twice the maximum of 12.5mg, I am going to take it less often because I will be getting some from B6 from food.
Supplement information for Nutri-meds B6 which shows it is pyridoxal-5-phoshate 25mg
It will be interesting to see if the US revise their upper limit which is currently an outlier and/or whether upper limits for different B6 forms will be considered.
It is unfortunate that the story did not specify his total supplemental dosage B6 dosage and form or whether the supplements he used were tested to find out whether they contained what they claimed.
Thanks for this I've been using P5P for years now and this proves what I found symptomatically to be actually proven science. So many medical staff scoff at my using nutritional supplements and say that pyridoxine - the only form of B6 in the British National Formulary is the only one I need. Of course I ignored them. It took some time to tolerate the dose I need, but it transforms my life. Now I can tell them that actually pyridoxine is harmful.
I don't have a link, but I found that thyroid antibodies not only attack B12, but also attack an enzyme in your brain called glutamine synthase used to keep up the glutamate, glutamine, GABA cycle. P5P is it's coenzyme and so it's not surprising that it helps, as build up of glutamate causes signalling issues in the brain. It also helps as a coenzyme to diamine oxidase (DAO) that helps reduce histamine.
I also use TTFD instead of normal B1 as it can enter cells with out help. When you don't have enough B12, you don't have enough methyl donors, especially if, like me you are asthmatic and use methyl groups to make up for lack of sulphite oxidase (SOX). If you can no longer methylate folic acid then the folic acid binds to B1 and destroys both. It's no wonder we get so sick with thyroid and B12 issues.
My GP wondered why I didn't get better from being given thyroxine when it wasn't just the lack of thyroxine that is the problem. They just treat me like I'm the problem. That it's just a placebo and poor thing is so ignorant. Yeh, right. xx
Thiamine tetrahydrofurfuryl disulphide , a synthetic derivative of thiamine , also known as Vitamin B1 . It is more soluble and bio available than thiamine .
The NHS routinely prescribes the cheapest and often least effective forms of any supplements, but why should that be a surprise since they appear to know next to nothing about any of them!
Though some might suggest that the UK's adoption of hydroxocobalamin for injections was a good move. (Even if the aim was, at least in part, to extend injection intervals.)
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Help interpret my results... Bad hairloss! 
How long before B12 peripheral neuropathy starts to go away?
High Dose Vitamin B6 and B12 Supplements Appear to Cause Lung Cancer in Male Smokers
Assay, Assay, Assay
Acceptable Rise in B-12 Levels?
