Cerebralspinal fluid and vitamin B12 not crossing the blood brain barrier.

[Oneash]

I found this interesting research...medicalxpress.com/news/2024...

And wondered if you guys knew anything more on this subject? Should those with more severe neurological issues get their cerebralspinal fluid checked? Should we all be on immune suppressants?

It just shows there is still far more to know about how vitamin B12, and nutrients in general, work in the body. Anyone doing dementia research should be checking.

It's important to note that the patient's blood serum B12 levels were NORMAL.

#CSF

[Oneash]

Admins can you edit this to say 'cerebral spinal' with a gap. It might search better.

[helvella in reply to Oneash]

Though cerebrospinal, or even CSF, might actually be better targets for searches!

And you do not need an admin to edit it:

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[Oneash in reply to helvella]

Fairysnuff!

[PlatypusProfit8077]

I shared the medical research article a few days ago - it was very jargon filled so this article was actually easier to read!

It’s so interesting isn’t it? I wonder if you could argue that anyone with neurological symptoms that appear before the usual haematological symptoms has this issue.

[Wwwdot]

Hi Oneash

Fascinating and something we all shoukd be aware of.

My reflexology lady mentioned some research where no B12 was found in spinal fluid of diagnosed dementia patients- I wonder if this is what she is referring to? I will ask her.

It goes to show that as dementia is a B12 symptom and that B12 in the blood is only a first stage location, better safe than sorry would be to supplement B12 at signs of dementia and see what happens.

I have my mum on a B12 oral supplement as her levels were low at around 400 ish ng/l and she’s just tested around 600 and I have noticed that shes cognitively much more sharp. She used to tell me things two or three times but not now. Not very scientific or a large experiment with only one bod - but interesting!

🤶🤶🤶

[CRK1 in reply to Wwwdot]

I have PA and am well aware of the effects on my thinking if I don’t have enough B12. My mother is 95 and had a slump recently. Didn’t feel like getting out of bed, couldn’t think clearly. I suggested B12 night help. She is in UK so NHS useless for this. Took her private and with weekly shots so much more herself. Did this stave off dementia? Possibly but certainly made a big difference. She lives alone and can well take care of herself again and is in a much better mood.

[Wwwdot in reply to CRK1]

Hi CRK1

Yes I notice it in my thinking too - if I miss a jab just trying to work out what to eat can be too challenging. I start to feel out of sorts and unable to cope with simple things which is so not me!

That’s great news about your mum! She sounds incredible! Where abouts in the UK is she?

🤶🤶🤶

[CRK1 in reply to Wwwdot]

Cheltenham

[wedgewood in reply to CRK1]

I’m in Cheltenham too . I find Gloucestershire the worst place to be if you have P.A./B12 deficiency. That’s no praise for other counties though !

Really pleased to hear how your Mum has improved ! Well done you .

[bookish in reply to CRK1]

Brilliant that you found some help for your mum. May I ask, was it a private GP or BUPA etc or did you use an aesthetic clinic or similar? Struggling with my dad. Cheers.

[Oneash in reply to CRK1]

My late mum was on B12 tablets, she died in 2021. She was initially diagnosed with dementia, then latterly B12 deficiency. I got Covid 2023, then got worse, partly because I'd talked about mum with the nurse I got my diagnosis and loading doses. I can't help but think if mum had been on injections she might have had a much better last few years.

[Wwwdot in reply to Oneash]

Hi Oneash

I feel for your grief Oneash as I feel the same about my father. He suffered terribly with unknown illness and eventually declined and died of bowel cancer - he was relatively young and recently retired when he died but has suffered for around 15 years.

It’s only since my diagnosis that we now realise his mother died young from an autoimmune disease and likely my father had untreated PA.

I console myself by knowing my dad would take comfort in that his suffering gave me the knowledge to live a better life. He would have wanted that for me like I feel sure your mum would have wanted for you.

🤗🤗🤗

[CRK1]

private GP in Cheltenham. Luckily she has financial resources.

[wedgewood in reply to CRK1]

I also went to a private GP in Cheltenham when my GP sent me on my way with numb feet , breathlessness, brain fog , dizziness and tachycardia. He did the IFAB test which was positive (. Dr P. )