I have hypothyroidism, elevated B12 and elevated MCH. No one knows why. Has anyone experienced this and do you know how to correct it?

[Jeannebon46]

I have hypothyroidism, elevated B12 and elevated MCH. No one knows why. Has anyone experienced this and do you know how to correct it?

[wedgewood]

if you are not supplementing vitamin B12,, an elevated level of B12 blood serum can mean that vitamin B12, is not getting into your cells ( it’s called functional B12 deficiency ) This can result in enlarged red blood cells. Enlarged red blood cells ( high MC H ) means that they are too large to get where they are needed )

This calls for liver tests investigation by your GP . I cannot understand why your GP hasn’t instigated an investigation. into this . . Are you experiencing B12 deficiency symptoms ? ( look them up There are many . You won’t have them all , just a select few. )

If your GP does not investig@ate this situation , change your doctor or surgery .asap

I am not medically qualified but i know that it needs thorough investigation.,

When you say “ No one knows why” , do you mean your doctors don’t know why ? If that is so, it’s very neglectful not to be investigated.

Best wishes.,

[FlipperTD]

Scientist, not medic.

Hypothyroidism often presents with a macrocytic picture. To further complicate the matter, B12 and/or folate deficiency can also present with macrocytosis.

Once the hypothyroidism has been treated, then the macrocytosis will usually resolve in a matter of a few months.

It's a good idea to have B12 and folate levels monitored at this stage, before B12 replacement therapy has commenced. If B12 injections have been started before this point then further testing of B12 is usually unhelpful, and can be misleading.

[Sleepybunny]

Hi,

High B12 levels without supplementing B12 and without having B12 injections can sometimes be the sign of a serious health condition.

I would expect your doctor to check liver and kidney function, order a full blood count (FBC) maybe some other blood tests and to consider referring you to a specialist if you are not supplementing B12 or having B12 injections.

It's possible to have severe B12 deficiency symptoms with normal or even above range serum B12 results.

MMA, Homocysteine and Active B12 (holotranscobalamin) tests can help to diagnose Functional B12 Deficiency.

I'm not medically trained but my understanding is that people with Functional B12 deficiency would usually be treated with B12 injections.

Lots more b12 info in pinned post "Various PA/B12D resources".

It can be helpful to know which country you are in as this can help people to post relevant information.

B12 websites

PAS (Pernicious Anaemia Society)

Based in Wales, UK.

pernicious-anaemia-society....

There is a helpline number that PAS members can ring.

B12info.com

b12info.com/

Run by a UK campaigner on B12 deficiency issues

B12 Awareness (US website)

b12awareness.org/

Stichting B12 Tekort

(Dutch website with English articles)

stichtingb12tekort.nl/weten...

B12 Institute - Netherlands

Has useful list of symptoms.

b12-institute.nl/en/home-2/

Two useful B12 books

Published a few years ago so some bits may need to be updated.

"What You Need to Know About Pernicious Anaemia and B12 Deficiency" by Martyn Hooper

Martyn Hooper is the former chair of PAS (Pernicious Anaemia Society).

"Could it Be B12?: An Epidemic of Misdiagnoses" by Sally Pacholok and JJ. Stuart (USA authors)

Very comprehensive with lots of case studies.