Wondering if anyone else has had the same problem from switching from rotexmedica/Panpharma hydroxy to other brands? I injected a Pascoe hydroxy today and it’s done absolutely nothing - like injecting saline. All my symptoms roaring back after being under control for 2.5 years with rotexmedica.
Are the Hervert brand any better?
I have tried all 3 ~Panpharma, Pascoe and Hevert B12 DEPOT and they all worked well for me . I could not distinguish between any of them . Sorry that you have had that strange reaction. Maybe to do with different preservatives? Just looked at the ingredients . They both contain Hydroxocobalaminacetate and Sodium Chloride( salt)
But Panpharma has acetic acid ( vinegar) and sodium acetate , which is a salt of acetic acid ,,which Pascoe does not have . Perhaps other members have an idea what might have happened. Best wishes .
Best wishes .
thank you for your reply and for checking the ingredients! I think it must be to do with the difference in ingredients.
I’m belatedly remembering that when I needed folic acid injections for about 18 months (I had SIBO and couldn’t absorb folate supplements), Hevert worked very well, and Pascoe didn’t work at all. Might be something to do with my biochemistry.
Oh dear .Is it worth trying one more?
I reacted twice to different preservatives in s certain brand.
Bug rather thsn dk nothing it made me ill.
Will have to check again and compare to pascoe hydrox.
I do hope you find s second injection works or find an alternative
thank you - it’s valuable to be able to compare to your experience. I agree, I don’t think I’m having an adverse reaction - just no reaction at all, for some reason!
I have had that with my usual hydrox before No idea why .
Did nothing???
Hope not a dodgy batch ??
Ones I've had and okay on;
Accord
Rotexmedica ( as still have some left)
Gerot and lannoch
Neo cytomen
All hydroxcobalamin
The one I personally can't tolerate is
Cobalamin H
An extra or different additive .
A past member fbirder identified.
Pharmacy now have a note not to give me that one.
I initially thought a surge of horrid symptoms.
But when it happened again .
Clear it was the brand .
I
hi, I’ve also found pascoe to be fine, just wondering if something else in your life has worsened your b12d? Mine was worse when I took diabetic meds (metformin) for example… good luck xx
it’s definitely the Pascoe B12, it was remarkable how dreadful I felt after the injection, and when I did a rotexmedica injection six hours later, the symptoms immediately began to improve and I’m 95% back to normal today.
Maybe because you didn't inject the full dose?
Hi.. can I ask how often you are injecting and what symptoms came back after using Pascoe ?
I inject every 48 hours. Symptoms that came back were peripheral neuropathy and paresthesia in my left side, nausea, diarrhea, and lightheadedness.
One theory is that because the pascoe is a higher dose.. 1500mcg compared to 1000mcg.. that it is actually doing more and what you are experiencing are reversing symptoms... where your nerves are waking up and healing.Are you taking co factors to support your injections?
you’re absolutely right about reverse healing - I anticipated that and deliberately only injected 2/3 of the Pascoe ampoule so that I received the same dose of B12 as one rotexmedica!
I think I’m covered on the cofactors side - methylfolate, b vitamin complex without B6, lactoferrin for iron, magnesium phospholipid complex. And eat lots of coconut produce for potassium.
Thanks for helping me troubleshoot! 
It seems you have co factors coveredAs for only injecting 2/3 of the ampoule... I've never heard of anyone doing that
Most of us that used to use panpharma started using pascoe some months ago.. I switched over around 6 months ago...
I thought it was an absolute bonus that they are 1500mcg
Our bodies will only take what it can use from each B12 injection.. and the rest will be peed out.. there is no danger of having too much
Personally... I would inject the whole ampoule and see how you get on... its hard to work out what's going on after only the 1 partial injection
Me too, nearly £90 down the drain - I was injecting 4 a week before giving up on them. Symptoms returning including neuropathic head to foot itching - the one symptom guaranteed to drive me insane. Rheumatologist has recommended Gabapentin with all its potential side affects. Trying CyanocoMinn prolonged release tablets 1mg x2 per day and, for the moment, itching is very much reduced (but then it's only 3 weeks since my B12 injection from the surgery which I always found more effective than Rotexmedica)
It may be that the symptoms you were getting were reverse symptoms... So rather than the injections not working for you..they were actually working better and healing
Unfortunately they are symptoms that return whenever I stop injections (before seeing specialist ..... ever hopeful ... waste of time!). Have been injecting since 2017.
reassuring to know I’m not the only one! I’m so sorry your symptoms are returning, head to toe itching sounds like hell. I might try those prolonged release tablets you mention. Hopefully rotexmedica becomes available for us again soon!
These tablets may not be working - it may be my surgery injection a few weeks ago. They were relatively cheap at £5-6 but you could be wasting your money!
me too! I SI once a week and started on pascoe 4 weeks ago, since then symptoms started returning, tingling, tiredness, headaches, low mood and irritable..I thought i was tired and needed more b12. Glad I found your post, as it makes sense to me now.
I’ve ordered the hevert brand, so fingers crossed 🤞 as i’m panicking and not feeling great at all.
I hope you manage to find something that works for you x
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