Protein deficiency and B12?

[WiscGuy]

I was diagnosed with B12 deficiency with neural symptoms in the spring of 2021. After bouncing around in treatment that I later learned was appropriate for hematologic symptoms, in August of 2021 I began injecting cyanocobalamin daily, and have continued since. Some symptoms improved, others did not, reappearing some days but not others, and I suspected that something other than B12 deficiency might be responsible for symptoms that did not improve. In July of 2022 I had a pacemaker implanted, and additional symptoms improved, while others did not, reappearing some days but not others, and again I suspected that something else was going on. A couple weeks ago, suspecting that I was getting less than the recommended amount of protein, I began taking a whey protein supplement. I felt better immediately, but then the old persistent symptoms (brain fog, headache, generally feeling ill) returned, reappearing some days but not others.

Has anyone here noticed a connection between protein deficiency and B12 deficiency?

While looking for a possible connection between protein and B12 deficiency, I came across this quite-old abstract:

sciencedirect.com/science/a...

Absorption of Co58 Labeled Cyanocobalamin in Protein Deficiency: An Experimental Study in the Rhesus Monkey.

Gastroenterology, Volume 46, Issue 2, February 1964, Pages 167-174.

Summary

A study of intestinal absorption of Co58 labeled cyanocobalamin was made in a group of rhesus monkeys in whom a picture of uncomplicated protein deficiency closely resembling kwashiorkor was induced.

Markedly diminished absorption of Co58B12 was observed in the deficient animals. The defect could be completely reversed by protein repletion. The results suggest that damage to the intestinal epithelium and probably deficiency of intrinsic factor may be responsible for the observed absorptive defect.

This study may be relevant to an understanding of tropical sprue and tropical megaloblastic anemia.

[Technoid]

Low Stomach Acid is common with Pernicious Anemia and along with causing many digestive and absorption problems, it can cause inefficiency or problems with breaking down proteins for digestion. Older adults are often recommended to get at least 1.0 to 1.2g/kg bodyweight daily total protein. You can track this in an app like cronometer to see what a typical days protein intake looks like for you.

[deniseinmilden in reply to Technoid]

That's a really interesting ball-park guide, thank you! (Was it in the Macronutrient course? I've yet to complete that one. Thank you for those too).

[Technoid in reply to deniseinmilden]

np No its from page 4 of this article from the journal "Nutrients"

ncbi.nlm.nih.gov/pmc/articl...

[deniseinmilden in reply to Technoid]

Thank you!

[WiscGuy in reply to Technoid]

Interesting article!

[Treesong2023]

WiscGuy, I am pretty sure you have already ruled out gluten intolerance? And tried a keto or maybe close to keto diet which is more protein orientated. Just saying what popped in my head is all.

As the more I read, the more I see that we all seem to have unique metabolisms....

With each of us searching and tinkering with foods and meds to get the best, or better outcomes.

I am glad you have seen some success in your efforts..

But this body tinkering....it reminds me of my dad keeping his old " vintage" French motor car going. More magic than mechanics.

Sending kindest regards.

[Nackapan]

O wonder if chicken or egg.As when we start absorbing less from the same diet that has kept us well for years ,protein levels drop as well as everything else.

I wonder if more education on nutrients woukd suggest a change in the way we eat if absorbtion slows.

Also our earth and food is changing.

Also far less exercise for the majority.

Which utilises food in a different way.

Sroring 'excess' in s different way.

Just thoughts 🤔

[FlipperTD]

The 1964 article is a cracker, and is a splendid piece of work although the monkeys might not agree with me!

The references in the article are from some classics, such as William Bosworth Castle, who proved the existence of Intrinsic Factor, and Mollin & Booth, who showed the absorption of B12 in the small intestine.

If this doesn't show how important a well-balanced diet is for health, I don't know what will.

Thank you for your diligence, and a Happy New Year coming soon.