It is unclear how the cost of £3.50 was derived and it sounds from other comments that it is about consumables and does not include capital costs.It isn't clear in the article that the test would really improve diagnosis as there is still a significant grey area. The test is still only measuring levels in blood and in general active B12 is 20% of total ...
There were frequent references to differences in opinion and the need for more research.
Holo-T (US) / Active B12 (UK) does seem to be getting more common which suggests to me that the capital outlay has been the most significant inertia factor.
Interesting that The Doctors Lab, which services a large proportion of the private healthcare in London (as well as some NHS, I think), switched to default to Active B12 a considerable time ago.
I was given an active B12 test by a Haematology department in a major London hospital in 2017. I believe that this is their standard B12 test now. I was only given a result of "normal" (over 128) - as Nackapan noted above - which wasn't surprising as I had been having injections twice a week, then reduced recently to one a month.
I think at this stage of my treatment it was quite pointless.
Yes, it may well have been useful before injections started, but serum total B12 was found to be below range anyway (just). It would have been interesting to know what methylmalonic acid (MMA) levels were like then, too.
Folate and ferritin were both low within range, but still treated just in case this was adding to problems- GP believed it might explain hair loss and bleeding gums for instance. Vitamin D was prescribed as part of treatment for osteoporosis of the spine.
Despite B12 injections, I got worse. Despite now high serum total B12 level, my MMA was found to be raised. This was confirmed as functional B12 deficiency, any renal problems having been ruled out first. My GP sought advice and from then on, I received 2 injections a week for 6 months.
At this point, I stopped improving and got worse again- injections were reduced to one a month and I was sent to various consultants for more tests. SIBO was ruled out, Coeliac disease too. Nothing else was found apart from "patchy gastric metaplasia" and "flattened mucosal pattern" in duodenum - the cause/s for which were never explained, or perhaps not discovered.
In the end, I started self injecting, initially every other day. Now twice a week.
I am much improved, but it has been very slow and I still get some symptoms.
It took about two years to get folate and ferritin to stabilise at healthy levels, three years for MMA to fall into normal range - on the 6th test. Osteoporosis has now been downgraded to osteopenia - so effective treatment for that continues too.
(MMA should drop down to a normal level after loading injections - when B12 replete.)
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