I'm new to the site and only just aware of my B12 deficiency in last couple of weeks, though had undiagnosed symptoms for months previously. I've got 1 loading injection left to go.
Methylcobalamin drops are they effective? I got some from Germany but haven't heard any mention on the site yet.
Can you mix them with Hydrocabalamin injections on different days?
No. They are no more effective than oral B12. That means, if you have PA then they will do nothing. The B12 molecule is too large to cross biological membranes unaided.
But give them a go - it cannot do any harm (although be aware that some people have a strong adverse reaction to methylcobalamin in large amounts).
Yes, you can take them any time while you are on injections. B12 is non-toxic, so you cannot overdose.
I tried the Methylcobalamin drops and got really bad palpitations...and numbing in left arm...is that the adverse effects you talked about? Not sure if its going to be short lived?
Not pleasant.
Ny7C - there is very little difference between sublingual and high dose oral. Both rely upon passive absorption outside the ileum. This is, however a very hit and miss process. Although the average is 1% by passive absorption there is considerable variation and for some people it is much lower than this. The success or failure of passive absorption isn't related to whether you have PA. Studies looking at it as a delivery method (admitedly small scale studies in general), seem to find rates of success that hover around the 70% mark regardless of absorption problem. They are worth giving a try.
The mechanism for passive absorption isn't actually understood at the moment.
Some people do experience anxiety from methyl but then others experience that with hydroxo and not with methyl. Very individual thing.
Thanks Gambit 62....it's good and reassuring to have someone who understands and has experience of the subject, especially when it's a whole new subject to deal with.
I didn't experience noticeable anxiety with the hydroxo....so far anyway! So yes it does seem a very individual thing.
Passive absorption is well understood. It is simply the movement of molecules from an area of high concentration to an area of low concentration.
What isn't understood is...
Why it seems to have a limited capacity. Why only 10 mcg can be absorbed.
Why the amount absorbed from an oral dose of 1 mg is the same as the amount absorbed by a sublingual dose of 1 mg. You would expect some to be absorbed sublingually (say 10 mcg) and some of the 990 mcg that is swallowed to be passively absorbed in the gut (9.9 mcg). So a sublingual dose should put twice as much into the body as an oral dose.
Why people have given up trying to develop a B12 suppository. If it is absorbed by passive diffusion then it should be absorbed much better rectally than sublingually (as it is in contact for a longer time).
Why we don't passively absorb the B12 made by our gut bacteria.
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