Parietal cell antibodies / myocardial antibodies

[Maggiez]

Hello. I was infected with h. pylori and was prescribed antibiotics and antacids as a treatment. The combination of the infection and treatment destroyed my stomach. My body created antibodies against my gastric parietal cells and my heart, myocardial antibodies. I am constantly bloated and have heartburn. My chest hurts and I always have digestive discomfort and I am always tired. All of my other labs are normal for now. Does anyone have experience with parietal cell antibodies or myocardial antibodies and how to manage? Thank you.

[Hidden]

Hi Maggiez sorry to hear you’ve had this horrible bacteria.

I’ve been treated a few times over the years for this,last time I had to have extended courses of treatment because it was a particularly bad bout I had.

It’s been 6 months now since my last session of treatment and I had the breath test done to confirm it was dormant

I had a bad time with my gut too the combination of the pylori bacteria then the treatment itself is what does all the damage I’m just in the process of optimising my b12 b complex and d3/k2 and this week I will also start on high dose vit c as it’s antibacterial.my gut has been so much better since starting this regime and of course my diet is better than it’s ever been ,strictly no gluten and no lactose and cook from scratch,we have to be so careful now and build our gut biome back up so kefir or probiotics can be good but you’ll have to do loads of research because the gps are useless,no one told me the infection would destroy my gut and that Not having the ability to absorb all these vitamins from my food would make me so ill with deficiency’s it’s so hard to do on your own but you’ve no choice,just keep reading and researching and asking questions and hopefully you’ll get some answers,take care x

[Maggiez in reply to Hidden]

Thank you. I did eradicate the bacteria but my gut is destroyed. I started b12 injections on my own, going to a medspa and paying for it. I have done a ton of research and more to do. I am doing loading doses now as I have showed many symptoms of b12 deficiency. I will do more blood work soon to be sure I have not become deficient in other vitamins. I’m gluten free vegan with an excellent diet high in greens, fruit and vegetables. I am taking a high dose probiotic. I’m sorry you’ve experienced this horrible ordeal as well.

[Hidden in reply to Maggiez]

Hi Maggiez glad to hear your getting on top of it you know it stays in your bloods you’ll always test positive but it’s only by having stool tests or breath test done that you can confirm it’s active again.I was deficient in everything incl folate because of it and I had the MMA test done two weeks ago which came back over the range so they then suggested I see gp for intrinsic testing and parietal cells for pernicious anemia but I was advised because of symtoms to go ahead with injections as I was obviously b12 deficient.ive bought all the stuff in to do them but I’m so scared of it I’ve not plucked up the courage yet I’m a born coward with needles.

First time I had HPylori was about 12 years ago and it was a spanish gp who told me I had it but my daughter also had it as a youngster,she’d picked it up from travel abroad with school,I’d got it from holiday to Jamaica.

[Maggiez]

Thank you. I’m in the US.

[Statesideheather]

I've only had experience with B12 deficiency, as far as I'm aware.

Bloated, heartburn, chest pain, digestive discomfort and exhaustion are all but a few of the symptoms I experienced with deficiency. It took quite some time for those symptoms to begin to subside. Over a period of 4.5 years I've felt improvements. The most improvement and best I've felt has been the past 10 months or so that I've injected every other day.

I can't offer much about your specific issues but I can say that to me, it seems like the B12 may well be what you need to feel better. Though, you might need more of it to get there.

I'm also in the US and eventually I began ordering the B12 from Canada as it saves me a lot of $$ and I have more free on when I can do it myself.

Hope you're feeling better soon!

[Maggiez in reply to Statesideheather]

Thank you, Statesideheather. Where do you get your B12? It is very expensive to get the injection from the medspa and I would need a prescription to get it from a compounding pharmacy where it is cheaper. The last time I went to my clinic, the nurse agreed to give me a b12 shot then ordered a blood test right after. When my results came back, my b12 levels showed high and the doctor refused to give me anymore. :/ Recently, I’ve been experiencing more symptoms like ringing in my ears and ulcers in my mouth in addition to my other symptoms. The antibodies against my parietal cells is a big problem with my digestive issues.

[Maggiez in reply to Statesideheather]

How long have you been getting injections? How many have you had? I was planning on a loading dose of 7 and then once a month for maintenance. I’ve only had 3 so far. I don’t feel any better. I’m not sure if it will help in healing my stomach lining and stop the parietal cell antibodies.

[Statesideheather]

I order from buy-otc.com

It is in BC. I found out about it from this group. I've been ordering the 10 ml vials. Once the seal is compromised, they need to be used up within 28 days. I keep mine in the fridge, double bagged once opened. I also use a fresh paper towel as workspace every time. When the bottle is new, I swab the whole thing with alcohol. After that, I always swab the stopper before and after use. Any contamination can lead to bacterial growth which would not be good!

I first ordered syringes from the same site but found I can buy a box of #100 at Walgreens for around $20. But now I get a box of #100 at Costco for less than $13. I have to ask the pharmacist and show ID. Also, sorting out how to dispose of used syringes is tricky. Your local waste company may have containers and accept them but there is likely a charge. It is not legal to put them in the trash.

I watched many YouTube videos before I worked up the nerve to do it myself. I previously had gone to med spas and naturopath for injections.

I never had loading doses. I started with oral doses. I had a huge improvement with that but it stalled. I became constantly dependent on sprays and lozenges so I went to all medspa once monthly. After a few months, I was able to narrow down the time I benefited from the one injection. I knew I needed more often. So I went to naturopath and tried twice monthly for a few months. Then I moved to weekly. It was getting expensive so I got up the nerve to try it myself. I was hoping twice a week would be good. A few months of that and I finally got to every other day and that it what it takes to stay my best.

I hope to need less at some point. But, my theory is that absorption isn't the problem so much as retaining it or the recycling system not working. It's just my theory 😂 but it means that, for me, I must provide my body with the B12 it needs almost daily. Other people have a large amount stored in liver that is constantly recycled through a complex system. Without any of that, I need to inject it. So I liken it to insulin and just accept it is a constant. But I feel so much better than before!

Also, I make sure I take a B complex a few times a week as the cofactors are needed for proper B12 use.

BTW, I never had B12_levels checked. Long story but my phobia of medical stuff was amplified by deficiency. I am sure I was near death before I finally went a naturopath clinic. They could see I was anemic by the physical signs (white underlids, white palms, slow reflexes, etc), but I think iron was the assumption . It took me 3 months to finally submit to a blood test where they checked thyroid and a few other basics. What they found was macrocytic or megaloblastic anemia. I was not willing to do more testing so they started my on a supplement. After about 6 weeks, I started feeling alive again. It's been a lot of trial and error and working up to where I'm at now.

I have turned down any more testing. I am planning to see an osteopath and get a relationship going there so I can be sure I have a Dr aware of and cooperative with my treatment plan.

From reading others' accounts on here, and competent medical reports, it seems that treating symptoms is the only way to go. I'm always reading here about people being cut off because they have high blood levels of B12. It is ridiculous and also quite scary!

I hope you start seeing improvements in your symptoms. I

f B12 deficiency is causing any of it, you should see improvements but it can take a few months. I never had mouth ulcer but pretty much every other system in my body was affected. My eyesight even started to go. Pain everywhere. I lost weight. Paranoia, insomnia, vomiting, skin discoloration, bleeding gums, tremors, and on. It's hard for me to believe I was that bad off and able to heal so much.

[Maggiez in reply to Statesideheather]

Thank you for such a detailed explanation. I appreciate your experience and thoughts. I'm glad you're healing.

[fbirder]

About 80% of those with PA have antibodies to GPCs. But about 10 - 20% of normal people also have them. So it’s unlikely they will cause severe symptoms.

[Maggiez in reply to fbirder]

Thank you. I've read this statement many times before, but it's only now making sense to me. My folate and iron levels were normal last time I checked but I know it takes a while before blood work catches up to symptoms.

[Hidden]

Gastric parietal cells secrete hydrochloride acid which is essential for breaking down food so that it can absorb vitamins and other nutrients in the small intestine. It is also essential for killing pathogenic bacteria. I have had severe problems with this and suspect my parietal cells are very much compromised. In my cases it causes severe difficulties in and absorption and also high levels of bacterial and fungal overgrowth confirmed through laboratory testing. I’m in the UK. If you’re in a similar situation it could indeed be causing your symptoms. I’m convinced it caused mine. Gluten free and non dairy diet helps, high dose probiotics (80 billion a day) folic acid 400 ug and supplemental iron is my regime as well as every other day SI. Only now after 2 years do I feel I’m getting some improvement and it’s not straight line. I suggest you also have a fecal elastase test done if you are having absorption problems. It tests pancreatic sufficiently and it’s easy to do. Good luck.

[Hidden in reply to Hidden]

Hi Martin2812 did you have this tested privately or gp ?

[Hidden in reply to Hidden]

Fecal elastase is a standard NHS test fir suspected malabsorption. There are standard lab ranges and treatment regimes too

[Hidden in reply to Hidden]

Thank you.

[Maggiez in reply to Hidden]

Thank you. I plan to do some more blood work soon to check for other deficiencies and will ask about the elastase test.