NO/ONOO Cycle and Benefits of Hydroxocobalamin

[EllieMayNot]

Perhaps this article by Martin Pall, PhD explains why some need much higher doses than currently recommended and why hydroxocobalamin is the preferred form :

townsendletter.com/FebMarch...

Quoted from article (credit to Martin Pall, PhD):

Hydroxocobalamin Form of Vitamin B12

Hydroxocobalamin has been used for over 70 years to decrease fatigue in people with chronic fatigue, long before CFS/ME was a well-defined illness. It was shown in a clinical trial of patients with a CFS/ME-like illness that 5 mg intramuscular (IM) injections twice a week produced statistically significant improvements as compared with placebo.83 In this study, it was also shown that there was no correlation between initial B12 levels and response to hydroxocobalamin therapy, suggesting that the hydroxocobalamin was not acting primarily to allay a B12 deficiency. Lower doses of another form of B12 that were adequate to allay a possible B12 deficiency produce no clinical improvement, and other evidence also strongly suggests that high-dose hydroxocobalamin is not acting here to allay a B12 deficiency.84,85

Other uncontrolled studies have suggested that the hydroxocobalamin form of vitamin B12 produces clinical improvement in people with these multisystem diseases.1,86,87 It has been inferred that B12 is acting as a potent nitric oxide scavenger and that this is the probable mode of action in the treatment of these multisystem diseases. 1,87 People with these diseases report essentially across-the-board improvement in symptoms when treated with hydroxocobalamin, suggesting that it acts to lower the basic etiologic mechanism of these diseases, consistent with a nitric–oxide scavenging mechanism.

In order to act as a nitric oxide scavenger, hydroxocobalamin and the chemically similar aquacobalamin must have the cobalt at the center of the molecule reduced from the cobalt III form to cobalt II.88 Such reduction is a process that occurs in vivo and is necessary for all cobalamins to have vitamin B12 activity as well as for hydroxocobalamin to serve as a nitric oxide scavenger.

Nitric oxide does not have a direct role in the central couplet, but it does serve as a direct precursor of peroxynitrite, such that nitric oxide scavenging will inevitably lower peroxynitrite levels in vivo. It can be argued, therefore, that hydroxocobalamin will act to lower the peroxynitrite end of the central couplet by scavenging nitric oxide.

[Nackapan]

Very interesting. Can't say I understood all of that

[EllieMayNot in reply to Nackapan]

Can't say that I have a perfect understanding. However, the major takeaway for me was that breaking the NO/ONOO cycle is an important step toward healing from many chronic illnesses and high dose hydroxocobalamin is very helpful in breaking the NO/ONOO cycle.

For me this proves that perceived benefits from higher dosing are not caused by a placebo effect which many so called "medical experts" like to claim.

[Nackapan in reply to EllieMayNot]

Very true. I was told by a neurologist I was psychologicaly addicted to b12 injections and too much will harm me. I am and was at the time having b12 Injections 2 weekly!!!

He however didnt thank goodness put that on his letter to G.p.

[Cherylclaire Forum Support in reply to Nackapan]

...Yes, that would've been really difficult to disprove (the "psychological addiction" part) ...BUT as difficult to prove , hence the omission from GP letter I'm thinking.

As for too much harming you - again, where is the proof ? Why do consultants keep repeating a thus-far unsubstantiated statement ? What is the source of all this determined effort ?

There is beginning to be evidence amassing to the contrary in a recent clinical trial : that for some people, more frequent B12 is the correct treatment for their condition, and that this group could be easily identified - currently by stool sample. Unfortunately, the clinical trial has only used volunteers with confirmed PA diagnoses.

Thanks, EllieMayNot - new information always welcome !

[deniseinmilden]

Wow - thank you! That's a new piece of information to me and makes a lot of sense.

Most of all I'm heartened to see that someone is thinking about this and researching it! And coming back with a sensible therapy for ME/CFS.

Thank you! x