Hi, New here, but have followed for a while. My B12 has always been high. Asked Dr how it's possible to have almost every S/S of B12 def, but B12 is too high? I became suicidal and felt like I was losing my mind. Finally paid to see a Dr. outside of insurance and she tested me for food allergies and a mutated gene that prevents methylating folate, which came back positive and wants a "parietal cell w/ REFL" (?), Fasting serum gastrin and total iron and IBC tested & said homocycteine was too high.
Started L5MTHR (methylated folate) and B12 injections and the results were pretty immediate, but had up's and downs. Happy to report that I CAN'T EVEN BELIEVE I contemplated ending my life, day in and day out for months. Pain gone and numbness /weakness greatly improved. I'm soo happy to be back to my optimistic self. Primary said theres nothing wrong and my blood work is fine, "it's a good thing to have such hi B12". But then had no explanation as to why I felt like dying and was losing my mind. Can tell I need a B12 shot because 1st thing to return is a flashing in my lateral left eye (also the 1st thing to go away w treatment). Started getting cyctic acne w injections so started on a powdered methylcobalin, but it doesn't seem to help. I do feel so much better though. Don't want to slide back, but is the acne because I don't need the B12? Could this be PA?. Was hoping for guidance. Thank you so much for being here!! Test results:
MCH . 34-36 over several months . (26-34)
MCHC 35-36 over several months (31-36)
B12 Binding - 700 (800-2600)
B12 1300-1500 (211-911)
Homocysteine 14.5 (5-15)
Vit D 41 (highest its ever been with 10,000 iu supplements)
Ferritin 11 (8-252) (also have hemochromatosis, so i guess its good that its so low?)
Thanks for any help!!