I was diagnosed b12 and folate def Oct 2016. Received loading jabs over 2 weeks, then onto 12 weekly, i was still having issues and now 8 weekly. I had my first Neurology appt last week due to allsorts of neurological issues. He has ref me for a head and spine mri to rule out nerve damage etc, which i have April 10th, yes came through really quick for the NHS. He also ran bloods of MMA, Homocystiene, ferritin, folate and liver. He did say i may not be getting it at a cellular level. What might work for some may not work for you. He put on the blood form b12 functional and question mark. Now will the bloods still show something even though i am receiving jabs. I was only originally prescribed 1 month of folic acid back in oct 16, and gp said that will be fine. I have been taking 5mg folic acid over 3 days when my jab is due. Last one was 22nd Jan. The neuro did say if anything showed he will give me the treatment needed. Is it bad i am hoping something will show up. Last question is how long does the MMA, homocystiene take to come back with results. He did say he would write to my gp with results but im not a very patient person and will ring his secretary. Thanks
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faras66
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functional B12 deficiency is all the symptoms of B12 deficiency but with high levels in blood.
one possible cause is a reaction to high serum B12 which interferes with the transfer of B12 from blood to cells, leaving your cells without the B12 they need to do everything they do but you still have lots in your blood.
The tests that the neuro is running will be looking for waste products that build up when your cells don't have enough B12 - homocysteine and MMA
The good news is that B12 isn't toxic and the easiest way of treating a functional B12 deficiency is to keep your B12 levels really high so enough manages to get through
Thank you for replying and all the info. If it does come back showing functional deficiency, would the treatment be more regular injections. It sounds terrible but im really hoping something shows up.
more regular injections is likely to be the outcome - as it sounds as if your neurologist has some understanding of what may be going on given the investigations that they are doing.
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