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Pernicious Anaemia Society
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SubQ vs. IM

Hi I have been self injecting SubQ since June of 2016. It has been effective. I had neurological involvement but did not start out with the typical loading dose. I saw a functional doctor (here in US) and started once a week and still do. My questions is: what's the difference in injecting IM vs. SubQ? Since I have found much improvement, I believe it is working. Thanks!

3 Replies

Hi pslmt I think it is generally believed that intramuscular injections are more "efficient" and that is how I have been having them for the last 46 years.

You say "I had neurological involvement..." are you still having neurological symptoms?

Do you know what your Folate level is?

There is a complex interaction between folic acid, vitamin B12 and iron. A deficiency of one may be "masked" by excess of another so the three must always be in balance. Folic acid works closely with vitamin B12 in making red blood cells and helps iron function properly in the body.

I am not a medically trained person but there are others on here who will be able to give you good advice.

I wish you well


Yes and no. another question I wanted to post...When I get super stressed, I will feel the symptoms that have essentially gone away with the regime I am on of weekly injections. Does that happen to anyone else? I take vitamin D, a multivitamin with methylfolate also. My Dr. monitors my ferritin as well. Thanks!


There's no real difference between IM and sub-cut. One will be absorbed faster than the other, but there's no hard and fast evidence as to which. Both will deliver the same amount.


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