Excessive b12 blood results

Hi Dmcn85 Do you know what your serum Folate level is?

Symptoms of a folate deficiency can include:

symptoms related to anaemia

reduced sense of taste

diarrhoea

numbness and tingling in the feet and hands

muscle weakness

depression

Folic acid works closely with vitamin B12 in making red blood cells and helps iron function properly in the body. A deficiency of one may be "masked" by excess of another so the three must always be in balance.

I'm not a medically trained person but there are others on here who will be able to give you good advice

This paper discusses the causes of high B12

oup.silverchair-cdn.com/oup...

by far the most common cause of high B12 is going to be treatment for B12 absorption problems.

Levels in blood are only one part of the picture. There aren't any issues around B12 being toxic but there is a phenomenon called 'functional B12 deficiency - which seems to be at least in part down to a reaction some people have to raised B12 levels in their blood - they basically respond by shutting down the mechanism that allows B12 to pass from blood to cells - like building a huge damn on a river that stops water getting to anywhere downstream of the damn. Rather counter-intuitively raising B12 levels can resolve the problem - to go back to the dam analogy it is like letting the water behind the dam build up to the point where just enough trickles over the top.

Tests that can help to clarify if a functional B12 deficiency is going on are MMA and homocysteine - which are looking at levels of a couple of nasties that will build up if your cells don't have enough B12 to recycle them into useful building blocks.

Part of the reaction that causes functional B12 deficiency seems to be that the B12 then gets retained longer in the blood as well.

Unfortunately there isn't really much literature out there or many studies that I've come across in relation to functional deficiency and its treatment.

It may also be worth getting active B12 done as well as serum B12 - active B12 is B12 bound to a protein that enables it to pass from blood to cell. IN general it accounts for 20% of the bB12 in your blood but it may also be that there is something (probably genetic) going on that is affecting this ratio, meaning that you may not be as efficient at processing B12.

Liver problems can, I think, cause the liver to dump it's B12 stores leading to elevated B12 which could then kick off the problems above.

Your tummy problems are something that PA patents often have , due to the low/no stomach acid (Achlorhydria/Hypochlorhydria) that comes with PA.i had this and overcame the problem with probiotics which help the resulting upset stomach flora . I used Symprove which I eventually gave up because of the expense . But it helped enormously . I now resort to home made red cabbage organic sauerkraut ( with some onion , herbs and spices ) recipes on internet . This is cheap and tasty ! But any fermented vegs would do . It is an acquired taste ! I only found this out after seeing a gastroenterologist . I was insisting on a test for stomach acid , and he got a bit fed up and told me I couldn't have one , but that PA patients have low/no stomach acid . My GP didn't know this . I had to find a remedy myself . In fact my GP wanted me to take Gavescon which would have been the worst thing possible . Anyhow - no more tummy problems now ! Some people with this problem find help with drinks of diluted organic cider vinegar with mother . Some drink lime juice before meals , and bad cases find that betaine Hydrochloric acid capsules with pepsin help taken with meals , especially meat meals . Yours is a very unusual case the high B12 . Perhaps it's all floating round in your blood and not getting into your cells for some reason I had a very high blood serum B12 because of supplementing with tablets and wearing patches, when I was diagnosed with PA . Have you ever been tested for Intrinsic Factor Antibodies ? ( it's a very unreliable test actually , only about 50% accurate but it maybe worth a try ) Sorry about rambling so . Don't know if my ramblings are any help at all . But I was moved when I read your account Best wishes ,

Have you tried eliminating gluten ? I've found its intolerable, causing pain, bloating. My stomach isn't perfect without it but far better than I was.

I too had a very high B12 level last year just over 2000. I took a multi vitamin tablet daily, advised to stop that and the level came down to 1000. The Drs. didn't seem bothered even when it was at the highest level just said they were not concerned about it. I seem to be OK otherwise.

yourhealthbase.com/B12overl...

I think you'll find this link addresses some of your B12 issues. I have tested very high for B12 for nearly 3 years. I have never had B12 shots or supplements. I was referred to a Haematologist for a barrage of tests. All have come back normal. My active B12 was also high. If I'd never been tested for B12 I'd never have had to deal with this concern. I totally relate with you.

Dmcn85

I too have high B12, which the gp overlooked as well, these people are sickening me the way there leaving people to practically slowly die,

So I totally understand, I think it may have something to do with Diabetes, it can be a indication, and oh I am not on any supplements either, but also it may point to liver problems to!!!