Looking for good, pure multi-vitamins

[pslmt]

Hello. I'm looking for suggestions for a good, pure multi vitamin brand. I need methylfolate as I have mutation for MTHFR. I have PA and self inject so it does not need b12. Thank you!

[fbirder]

Just about everybody on the planet has a mutation in the MTHFR gene. The only mutation shown to have any possibility of a measurable effect is the C677>T mutation. And then only if you have two copies of it (about 9% of people). And most of those can get by without needing methylfolate.

[pslmt in reply to fbirder]

I have 2 copies of C677t..

[fbirder in reply to pslmt]

That means that you may well benefit from methylfolate. I would take 400 ug a day of methylfolate and eat a balanced diet for the rest of the B vitamins.

Taking methylfolate instead so folic acid will not do any harm, apart from to your wallet as it tends to be a lot more expensive.

I switched to methylfolate (I'm also Homozygous for the C677>T mutation) just to see if it made me feel better.

[Gambit62 Administrator]

some people with MTHFR actually report that methylfolate doesn't suit them. Have you tried folic acid and found that it doesn't work/makes you feel unwell.

[pslmt in reply to Gambit62]

because I have the genetic mutation I don't produce the enzyme necessary to complete the conversion of folic acid into 5-methyl folate. I assumed I wouldn't be able to take folic acid. I haven't tried the methylfolate yet. Just wondering if you know of a good brand of vitamin?

[fbirder in reply to pslmt]

People with the C677> T mutation can still produce methylfolate - just not as efficiently as those without the mutation. People with one copy are about 80% efficient - which means they can function completely normally (the body just makes more of the enzyme).

People with two copies are about 30% efficient. Many of them function OK with folates from the diet. Some will benefit from taking methylfolate supplements.

[Gambit62 Administrator in reply to pslmt]

pslmt - notice, looking back aty your posts that you seem to have tried methylfolate in the past and it didn't seem to agree with you

healthunlocked.com/pasoc/po...

[pslmt in reply to Gambit62]

The vitamin I tried had other things in it as well, so I am not sure if it was the folate or was it the other ingredients that didn't agree with me. This is why I was looking for advice of a good multi vitamin brand. I would like to try methylfolate again but with a simple combination of other ingredients. Thanks.

[Gambit62 Administrator in reply to pslmt]

any combination of ingredients and you aren't going to know if it is them or the methylfolate - would be better just to try methylfolate - I believe there were a few recommendations on your ealier post for that.

[pslmt]

okay thanks will do. I will try to find a good brand of methylfolate