It has been a while since I posted here but my symptoms have actually become worse on methyl B12 which is very strange with by b12 levels at 1000 + . My balance/cognitive functions have deteriorated since I received methylcobal injections (which was around 2 months ago) and I am currently supplementing with Jarrows 5000 mcg b12, 2 times a day. Finally today I urged my GP in India to send my folic acid report which I dont think he ever saw. It listed my folic acid level as 23.4 while the range is <5.38 ng/ml which is atrocious as i stopped folic acid supplementation 3 months ago and have only supplemented for around 2 months in my entire life! Could this point to the fact that my body might not be be able to process the available folic acid to folate which is actually resulting in worsening of b12 symptoms? Does methylcobalamin actually require folate to alleviate the symptoms? Sorry but my GP in india urged me to stop supplementing with folic acid and hence the question. What happens if I start on Jarrows methylfolate again? Will it actually do more harm than good? Apologies for the naive questions but I am really intrigued by how can supplementation have a detrimental effect. I am also thinking of getting tested for MTHFR. I was also researching on methylation protocol and could that be anyway related to cognitive decline/memory issues? I am pretty sure there are a lot of folks on this forum who might be having the same issue. Any pointers would be much appreciated.