I'm fairly new here and this is my first post. Has anyone had genetic testing for MTHFR polymorphism? I am awaiting genetic test results but based on my family history, my not-yet-managed B vitamin deficiency seems to be due to polymorphism. The defect is very common but affects people differently. My grandmother passed away in her early 30s, reportedly from leukemia. I'm now wondering if she was suffering from anemia linked to the polymorphism. Before my deficiency was discovered, every system in my body it seems began to fail. Knowing the reason doesn't really change treatment, but I'm sure it helps to know why some of us just cannot keep our levels up. It may also get the attention of practitioners who hesitate to treat or continue treating without Intrinsic Factor as the culprit. In the States, the genetic test is less than $100 out of pocket, through a medical professional. I believe the information on MTHFR polymorphism is also provided with commercial DNA tests such as 23 And Me. The MTHFR defects are a newer discovery and they are finding many diseases associated. One thing to note is that methylation is a huge factor. Folic acid and cyanobalamin can be toxic in a person with MTHFR polymorphism. This could explain why some of us react differently to different forms. Thank you to everyone for posting! I enjoy reading through them every evening. Learning a lot.