Homocystein a bit high. MMA in mid range.

[Knut666]

Does anyone know what will raise first in first stages of B12 deficiency. Methyl melonate acid(MMA) or homocystein.

And is there many of same symptoms between low B12, and B9 folic acid?

[Polaris]

Hi Knut666

You may find what you're looking for re. various stages of b12 deficiency, as well as MMA and homocysteine, on page 3 of the BMJ Research document below, which also has this information on folic acid:

"If there is noncomitant B12 and folic acid deficiency, then B12 must be started first to avoid precipitating sub acute degeneration of the spinal cord.

In patients with isolated vitamin B12 deficiency and anaemia, additional folic acid is recommended until vitamin B12 is replete to prevent subsequent folate deficiency after replenishment of B12 stores." :

cmim.org/pdf2014/funcion.ph...

................

Folic acid should never be taken while B12 is very low as it gets 'trapped', cannot be used, and could make neurological symptoms worse - info on folic acid in this video:

b12deficiency.info/films

.................

"Folate is required for the synthesis of red blood cells, those tiny disc shaped cells that carry oxygen in your blood to deliver it to each and every corner of your body. However, B12 is required in a reaction that converts folate into a form usable by the body to make red blood cells. Without that, folate cannot participate in the synthesis of red blood cells. So without B12, folate is literally of no use! ". - 'The B12 Deficiency Survival Handbook', by Dr Aqsa Ghazanfar

[Polaris in reply to Polaris]

Ps

Page 3 - BCSH Guidelines on B12 and folate deficiency:

bcshguidelines.com/4_HAEMAT...