Pernicious Anaemia Society
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haemo appointment

I am preparing for my appointment on Monday making sure I go with as much info and questions written down so I get what I need from the appointment. I have come across an email I sent when first diagnosed asking for advice. it has my levels from 2004 as 141, 154, 179, 179, 242 and after a weekly jab for 5 weeks it went up to 384. my mum had PA and I was constantly telling the drs how poorly I felt but it was only when they were doing bloods for thyroid that the nurse commented on the levels and said that it should have been looked at regularly. I have jabs now every 4 weeks and my GP has done my b12 which came in at 1103, 871, 871 even though I take sublinguals as well, cortisone was 366. just hoping my appointment goes well and they agree to more b12 as still got neuro problems and seem all over the place this last 10 months when I thought things were slowly getting better. x

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When you go to see doctor with info. Please do not back down. Be firm. I believe your detirmination is being tested.

Many years ago when I had problems, obtaining regular injections, I quoted how litte the cost of an injection is. In comparrison how important the injections are to my long term health.


i am definitely going in prepared and have written things down so i don't forget if they let me have my jabs more fab but if they don't this time i am self treating in the new year once i get my hands on some b12, thanks for your reply x

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I'm having a telephone appointment with my GP on Tuesday and this is part of the letter I am taking in tomorrow for her to read before. I hope it helps with me getting monthly injections. My B12 serum is 1500 but I still feel rubbish 3 weeks after an injection.

What is Active-B12?

Three carrier proteins are involved in the transport of Vitamin B12 around the body - Intrinsic Factor (IF), transcobalamin (TC) and haptocorrin (HC).

When transcobalamin and haptocorrin bind Vitamin B12 the resulting complexes are known as holotranscobalamin (HoloTC) and holohaptocorrin (HoloHC).

HoloTC represents only 10-30% of the Vitamin B12 circulating in the blood but is the ONLY form of Vitamin B12 that is taken up and used by cells of the body, hence it's other name... ACTIVE-B12.

Only transcobalamin transports Vitamin B12 from its site of absorption in the ileum to tissues and cells. The vitamin is then internalised as the Active-B12 complex via a specific receptor- mediated uptake. This process delivers Vitamin B12 into the cells of the body and provides the vitamin as an essential co-enzyme for vital cellular functions such as DNA synthesis. The remaining 70-90% of circulating Vitamin B12 is bound to haptocorrin, the function of which is unknown. Also, as Active-B12 has shorter circulating half-life circulating half-life compared to holohaptocorrin, the earliest change that occurs on entering negative vitamin B12 balance is very likely to be a decrease in Active-B12.

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