Study finds overabundance of opportun... - Parkinson's Movement

Parkinson's Movement
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Study finds overabundance of opportunistic pathogens in the guts of persons with Parkinson's

pvw2
pvw2

I'm wondering if this study shows any benefit to taking probiotics or any bacteria strains in particular:

news-medical.net/news/20200...

9 Replies
oldestnewest

I can't understand the study, but i take bio kult for getting bacillus subtillis in my gut. Definitely helps with regular motion.

parkinsonsnewstoday.com/202...

pvw2
pvw2 in reply to JayPwP

The problem with the article on the study is it doesn't tell us what the bad pathogens are. We can hope that bacillus subtillis will kill them.

JayPwP
JayPwP in reply to pvw2

The general understanding is that increasing gram-positive bacteria displaces and thereby removes the negative pathogens from our system. That is the reason for the huge pre & pro biotic market

chartist
chartist in reply to JayPwP

I don't think that is quite right as outlined in this article link below. Some gram- positive pathogenic bacteria can be quite bad for us!

healthline.com/health/gram-...

Art

sharoncrayn
sharoncrayn in reply to chartist

"We emphasize that no claims can be made on function based solely on association."

Well said.

pvw2
pvw2 in reply to sharoncrayn

But, apparently this study shows another PD symptom to deal with.

sharoncrayn
sharoncrayn in reply to pvw2

They do. Any pathogen that is opportunistic.

Rhyothemis
Rhyothemis in reply to pvw2

Any commensal can become pathogenic under the right (wrong?) circumstances, according to one of the researchers in this very long webinar (it's in there somewhere, I promise):

youtu.be/u8HU3JPtee8

Does something go wrong in the gut which contributes to the initiation of PD - or -does whatever it is that causes PD also cause changes in the gut microbiome? Could be either way and the paper does not answer this question.

What interests me about the paper is the Prevotella finding, which is contrary to previous studies. The authors attribute the discrepancy to use of different taxonomic classification systems. Prevotella can produce H2S and it has been suggested as a probiotic therapy for PD:

ncbi.nlm.nih.gov/pmc/articl...

Xylitol consumption encourages the growth of Prevotella.

Braak's theory, which this study is based on, is pretty theoretical because Braak never identified the pathogen which started or initiated the first of his 6 stages of PD. Hence, it has remained pretty much a fringe theory of what causes PD.

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